Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Gene Ontology Ratio Regulation Class description Accession Gene Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX Showing element 1143 to 1192 of 2667 in total
Gene Ontology  : membrane
Class  : cellular component
Ratio
Regulation
description
1.45148 up Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]
1.47697 Nck-associated protein 1-like (Membrane-associated protein HEM-1) (Hematopoietic protein 1). [Uniprot/SWISSPROT;Acc:P55160]
1.49264 Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1). [Uniprot/SWISSPROT;Acc:Q8TAV3]
1.50206 LAG1 longevity assurance homolog 4. [Uniprot/SWISSPROT;Acc:Q9HA82]
1.50284 down AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]
1.5415 Pleckstrin homology-like domain family B member 2 (Protein LL5-beta). [Uniprot/SWISSPROT;Acc:Q86SQ0]
1.54317 up Dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117) (DolP- glucosyltransferase). [Uniprot/SWISSPROT;Acc:Q9Y673]
1.58045 down Peroxisomal biogenesis factor 3 (Peroxin-3) (Peroxisomal assembly protein PEX3). [Uniprot/SWISSPROT;Acc:P56589]
1.60668 up Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0]
1.63713 Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). [Uniprot/SWISSPROT;Acc:Q9UH62]
1.6384 Olfactory receptor 6S1. [Uniprot/SWISSPROT;Acc:Q8NH40]
1.66123 KRAB-A domain containing 1 (KRBA1), mRNA [RefSeq_dna;Acc:NM_032534]
1.69658 down CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206]
1.72628 Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]
1.73291 up BTB/POZ domain-containing protein KCTD8. [Uniprot/SWISSPROT;Acc:Q6ZWB6]
1.74736 down Proline-serine-threonine phosphatase-interacting protein 2. [Uniprot/SWISSPROT;Acc:Q9H939]
1.75026 up Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]
1.75846 down Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]
1.80942 Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]
1.82063 Transmembrane protein 116. [Uniprot/SWISSPROT;Acc:Q8NCL8]
1.83601 up coiled-coil domain containing 90A [RefSeq_peptide;Acc:NP_001026883]
1.86433 CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4). [Uniprot/SWISSPROT;Acc:Q8IZR5]
1.89308 Ras-related protein Rab-36. [Uniprot/SWISSPROT;Acc:O95755]
1.93863 Olfactory receptor 2B2 (Olfactory receptor 6-1) (OR6-1) (Hs6M1-10). [Uniprot/SWISSPROT;Acc:Q9GZK3]
1.96673 Signal peptidase complex catalytic subunit SEC11C (EC 3.4.-.-) (SEC11 homolog C) (SEC11-like protein 3) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SPC21). [Uniprot/SWISSPROT;Acc:Q9BY50]
1.98149 CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]
2.27115 down RIM-binding protein 2 (RIM-BP2). [Uniprot/SWISSPROT;Acc:O15034]
2.45764 up zinc transporter like 2 [RefSeq_peptide;Acc:NP_598003]
2.48474 BET1 homolog (Golgi vesicular membrane-trafficking protein p18) (hBET1). [Uniprot/SWISSPROT;Acc:O15155]
2.4954 OMA1 homolog, zinc metallopeptidase [RefSeq_peptide;Acc:NP_660286]
2.54508 Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]
2.57202 Protein GPR107 precursor (Lung seven transmembrane receptor 1). [Uniprot/SWISSPROT;Acc:Q5VW38]
2.69364 Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase). [Uniprot/SWISSPROT;Acc:O43174]
2.79087 down leucine-rich repeat neuronal 6A [RefSeq_peptide;Acc:NP_116197]
2.8521 up transient receptor potential cation channel, subfamily M, member 1 [RefSeq_peptide;Acc:NP_002411]
2.85383 down Uncharacterized protein C20orf142 precursor. [Uniprot/SWISSPROT;Acc:Q8N6M3]
2.88128 CD302 antigen precursor (C-type lectin domain family 13 member A) (C- type lectin BIMLEC) (Type I transmembrane C-type lectin receptor DCL- 1). [Uniprot/SWISSPROT;Acc:Q8IX05]
2.88235 Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]
3.07625 Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). [Uniprot/SWISSPROT;Acc:O60637]
3.14866 up Transmembrane protein 181. [Uniprot/SWISSPROT;Acc:Q9P2C4]
3.27919 down Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]
3.31364 up Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7]
3.39764 down Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5]
3.41415 up Voltage-dependent calcium channel gamma-7 subunit (Neuronal voltage- gated calcium channel gamma-7 subunit). [Uniprot/SWISSPROT;Acc:P62955]
3.48558 Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2) (Tyrosine-protein kinase TYRO6). [Uniprot/SWISSPROT;Acc:P54753]
3.52215 down Olfactory receptor 4L1 (Olfactory receptor OR14-28). [Uniprot/SWISSPROT;Acc:Q8NH43]
3.54928 Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2). [Uniprot/SWISSPROT;Acc:Q8WTR4]
3.64872 up GTP-binding protein Rhes precursor (Ras homolog enriched in striatum) (Tumor endothelial marker 2). [Uniprot/SWISSPROT;Acc:Q96D21]
3.66058 down olfactomedin-like 2A [RefSeq_peptide;Acc:NP_872293]
3.76904 up Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV). [Uniprot/SWISSPROT;Acc:Q8N4S7]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/