MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1090 to 1139 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
4.71132	Pyruvate kinase isozymes R/L (EC 2.7.1.40) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) (Pyruvate kinase 1). [Uniprot/SWISSPROT;Acc:P30613]	molecular function	pyruvate kinase activity
			transferase activity
4.90535	DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2). [Uniprot/SWISSPROT;Acc:Q15038]		protein binding
4.93372	Ankyrin repeat and SOCS box protein 12 (ASB-12). [Uniprot/SWISSPROT;Acc:Q8WXK4]	biological process	intracellular signaling cascade
5.23046	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736]		G-protein coupled receptor protein signaling pathway
			negative regulation of apoptosis
			phosphoinositide phosphorylation
			phosphoinositide-mediated signaling
			protein amino acid phosphorylation
		cellular component	phosphoinositide 3-kinase complex
		molecular function	1-phosphatidylinositol-3-kinase activity
			inositol or phosphatidylinositol kinase activity
			phosphatidylinositol-4,5-bisphosphate 3-kinase activity
			phosphotransferase activity, alcohol group as acceptor
			protein binding
			transferase activity
5.32612	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx). [Uniprot/SWISSPROT;Acc:Q12968]	biological process	cellular respiration
			heart development
			inflammatory response
			regulation of transcription
			regulation of transcription from RNA polymerase II promoter
			regulation of transcription, DNA-dependent
		cellular component	cytoplasm
			nucleus
		molecular function	protein binding
			transcription coactivator activity
			transcription factor activity
5.61927	RING finger protein 170 (Putative LAG1-interacting protein). [Uniprot/SWISSPROT;Acc:Q96K19]	biological process	transport
		cellular component	integral to membrane
			membrane
		molecular function	metal ion binding
			nucleoside transporter activity
			protein binding
			zinc ion binding
5.83544	Nucleoplasmin-2. [Uniprot/SWISSPROT;Acc:Q86SE8]	biological process	chromatin remodeling
			embryonic development
			oocyte differentiation
			positive regulation of meiosis
			regulation of exit from mitosis
			single fertilization
		cellular component	cytoplasmic chromatin
			nuclear chromatin
			nucleus
		molecular function	histone binding
			nucleic acid binding
5.84607	Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]	biological process	axonogenesis
			beta-tubulin folding
			microtubule cytoskeleton organization and biogenesis
			protein folding
			protein modification process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.