MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Class	description	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1051 to 1100 of 2667 in total

Regulation  : down

Ratio	Class	description	Gene Ontology
4.4149	molecular function	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]	DNA binding
			protein dimerization activity
			sequence-specific DNA binding
			transcription factor activity
4.49282	biological process	Enhancer of polycomb homolog 1. [Uniprot/SWISSPROT;Acc:Q9H2F5]	chromatin modification
			negative regulation of gene expression, epigenetic
			negative regulation of transcription from RNA polymerase II promoter
			positive regulation of transcription from RNA polymerase II promoter
			regulation of cell growth
			regulation of transcription, DNA-dependent
			transcription
	cellular component		nuclear membrane
			nucleoplasm
			nucleus
	molecular function		transcriptional activator activity
			transcriptional repressor activity
4.49844	cellular component	Secretogranin-1 precursor (Secretogranin I) (SgI) (Chromogranin B) (CgB) [Contains: GAWK peptide; CCB peptide]. [Uniprot/SWISSPROT;Acc:P05060]	extracellular space
	molecular function		hormone activity
4.50619	biological process	Engulfment and cell motility protein 2 (CED-12 homolog A) (hCED-12A). [Uniprot/SWISSPROT;Acc:Q96JJ3]	apoptosis
			phagocytosis
	cellular component		cytoplasm
			cytoskeleton
			membrane
4.62042	biological process	Leukocyte antigen CD37 (Tetraspanin-26) (Tspan-26). [Uniprot/SWISSPROT;Acc:P11049]	protein amino acid N-linked glycosylation
			visual perception
	cellular component		integral to membrane
			integral to plasma membrane
			membrane
			plasma membrane
4.69231	biological process	Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (Polymorphic arylamine N-acetyltransferase) (PNAT) (N- acetyltransferase type 2) (NAT-2). [Uniprot/SWISSPROT;Acc:P11245]	metabolic process
	cellular component		cytoplasm
	molecular function		acetyltransferase activity
			arylamine N-acetyltransferase activity
			transferase activity
4.71132	biological process	Pyruvate kinase isozymes R/L (EC 2.7.1.40) (R-type/L-type pyruvate kinase) (Red cell/liver pyruvate kinase) (Pyruvate kinase 1). [Uniprot/SWISSPROT;Acc:P30613]	glycolysis
			response to other organism
	cellular component		cellular_component
	molecular function		magnesium ion binding
			potassium ion binding
			pyruvate kinase activity
			transferase activity
4.90535		DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2). [Uniprot/SWISSPROT;Acc:Q15038]	protein binding
4.93372	biological process	Ankyrin repeat and SOCS box protein 12 (ASB-12). [Uniprot/SWISSPROT;Acc:Q8WXK4]	intracellular signaling cascade
5.23046		Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736]	G-protein coupled receptor protein signaling pathway
			negative regulation of apoptosis
			phosphoinositide phosphorylation
			phosphoinositide-mediated signaling
			protein amino acid phosphorylation
	cellular component		phosphoinositide 3-kinase complex
	molecular function		1-phosphatidylinositol-3-kinase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.