MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Regulation	Gene Ontology	Class	Ratio	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1051 to 1100 of 2667 in total

description	Regulation	Gene Ontology	Class	Ratio
Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Uniprot/SWISSPROT;Acc:Q9GZN2]	down	nucleus	cellular component	3.48313
		regulation of transcription, DNA-dependent	biological process
		sequence-specific DNA binding	molecular function
		transcription factor activity
HORMA domain-containing protein 1 (Newborn ovary HORMA protein) (Cancer/testis antigen CT46). [Uniprot/SWISSPROT;Acc:Q86X24]	up	mitosis	biological process	1.22047
		nucleus	cellular component
Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	down	cell proliferation	biological process	1.23845
		cholesterol metabolic process
		endoplasmic reticulum	cellular component
		integral to membrane
		lipid metabolic process	biological process
		membrane	cellular component
		metabolic process	biological process
		protein binding	molecular function
		response to sterol depletion	biological process
		steroid metabolic process
Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]		extracellular region	cellular component	2.08208
		hyaluronan metabolic process	biological process
		serine-type endopeptidase inhibitor activity	molecular function
Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Uniprot/SWISSPROT;Acc:O75874]	up	carbohydrate metabolic process	biological process	1.19496
		cytoplasm	cellular component
		cytosol
		glutathione metabolic process	biological process
		glyoxylate cycle
		isocitrate dehydrogenase (NADP+) activity	molecular function
		isocitrate metabolic process	biological process
		magnesium ion binding	molecular function
		manganese ion binding
		metabolic process	biological process
		oxidoreductase activity	molecular function
		oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
		peroxisome	cellular component
		response to oxidative stress	biological process
		tricarboxylic acid cycle
Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]	down	carotenoid biosynthetic process		1.43088
		cholesterol biosynthetic process
		hydrolase activity	molecular function
		isomerase activity
		isopentenyl-diphosphate delta-isomerase activity
		isoprenoid biosynthetic process	biological process
		magnesium ion binding	molecular function
		peroxisome	cellular component
Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5]		biological_process	biological process	3.39764
		integral to membrane	cellular component
		junctional membrane complex
		membrane
		microsome
		molecular_function	molecular function
		muscle development	biological process
		sarcoplasmic reticulum	cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.