MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1051 to 1100 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Uniprot/SWISSPROT;Acc:Q9GZN2]	3.48313	down	biological process	regulation of transcription, DNA-dependent
			cellular component	nucleus
			molecular function	sequence-specific DNA binding
				transcription factor activity
HORMA domain-containing protein 1 (Newborn ovary HORMA protein) (Cancer/testis antigen CT46). [Uniprot/SWISSPROT;Acc:Q86X24]	1.22047	up	biological process	mitosis
			cellular component	nucleus
Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	1.23845	down	biological process	cell proliferation
				cholesterol metabolic process
				lipid metabolic process
				metabolic process
				response to sterol depletion
				steroid metabolic process
			cellular component	endoplasmic reticulum
				integral to membrane
				membrane
			molecular function	protein binding
Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]	2.08208		biological process	hyaluronan metabolic process
			cellular component	extracellular region
			molecular function	serine-type endopeptidase inhibitor activity
Isocitrate dehydrogenase [NADP] cytoplasmic (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP). [Uniprot/SWISSPROT;Acc:O75874]	1.19496	up	biological process	carbohydrate metabolic process
				glutathione metabolic process
				glyoxylate cycle
				isocitrate metabolic process
				metabolic process
				response to oxidative stress
				tricarboxylic acid cycle
			cellular component	cytoplasm
				cytosol
				peroxisome
			molecular function	isocitrate dehydrogenase (NADP+) activity
				magnesium ion binding
				manganese ion binding
				oxidoreductase activity
				oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]	1.43088	down	biological process	carotenoid biosynthetic process
				cholesterol biosynthetic process
				isoprenoid biosynthetic process
			cellular component	peroxisome
			molecular function	hydrolase activity
				isomerase activity
				isopentenyl-diphosphate delta-isomerase activity
				magnesium ion binding
Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5]	3.39764		biological process	biological_process
				muscle development
			cellular component	integral to membrane
				junctional membrane complex
				membrane
				microsome
				sarcoplasmic reticulum
				Z disc

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.