MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	Regulation	Class	Gene Ontology	description	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1051 to 1100 of 2667 in total

Ratio	Regulation	Class	Gene Ontology	description
1.43351	down	molecular function	carboxypeptidase activity	Carboxypeptidase A2 precursor (EC 3.4.17.15). [Uniprot/SWISSPROT;Acc:P48052]
			metal ion binding
			metallopeptidase activity
			zinc ion binding
1.44004		biological process	signal transduction	Cytokine-like protein 1 precursor (Protein C17). [Uniprot/SWISSPROT;Acc:Q9NRR1]
		cellular component	extracellular space
			soluble fraction
		molecular function	receptor binding
1.44789	up	biological process	humoral immune response	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Uniprot/SWISSPROT;Acc:Q16633]
			regulation of transcription, DNA-dependent
			transcription
			transcription from RNA polymerase II promoter
		cellular component	nucleus
		molecular function	DNA binding
			protein binding
			transcription coactivator activity
1.45148		biological process	Golgi organization and biogenesis	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]
			regulation of transcription, DNA-dependent
			vesicle-mediated transport
		cellular component	ER-Golgi intermediate compartment
			Golgi apparatus
			Golgi membrane
			Golgi stack
			integral to membrane
			membrane
			nucleus
		molecular function	DNA binding
			protein binding
1.45314			DNA binding	NULL
1.45624		biological process	circulation	Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]
			hemostasis
			multicellular organismal development
			regulation of transcription
			regulation of transcription from RNA polymerase II promoter
			regulation of transcription, DNA-dependent
		cellular component	nucleus
		molecular function	DNA binding
			protein dimerization activity
			sequence-specific DNA binding
			transcription coactivator activity
			transcription factor activity
1.45635		biological process	cell cycle	Cyclin-A2 (Cyclin-A). [Uniprot/SWISSPROT;Acc:P20248]
			cell division
			mitosis
			mitotic G2 checkpoint
			positive regulation of transcription
			regulation of cyclin-dependent protein kinase activity
			regulation of progression through cell cycle
		cellular component	cytoplasm
			female pronucleus

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.