MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1051 to 1100 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Uniprot/SWISSPROT;Acc:Q92844]	2.93895	molecular function	metal ion binding
			protein binding
			zinc ion binding
Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]	3.29064	biological process	liver development
			muscle development
			positive regulation of transcription
			positive regulation of transcription from RNA polymerase II promoter
			regulation of transcription, DNA-dependent
			transcription
		cellular component	nucleus
		molecular function	chromatin binding
			DNA binding
			metal ion binding
			protein binding
			RNA polymerase II transcription factor activity, enhancer binding
			sequence-specific DNA binding
			transcription factor activity
			transcriptional activator activity
			zinc ion binding
Transmembrane protein 116. [Uniprot/SWISSPROT;Acc:Q8NCL8]	1.82063	cellular component	integral to membrane
			membrane
Tripartite motif-containing protein 58 (Protein BIA2). [Uniprot/SWISSPROT;Acc:Q8NG06]	1.31489		intracellular
		molecular function	metal ion binding
			protein binding
			zinc ion binding
Tubulin-specific chaperone E (Tubulin-folding cofactor E). [Uniprot/SWISSPROT;Acc:Q15813]	5.84607	biological process	axonogenesis
			beta-tubulin folding
			microtubule cytoskeleton organization and biogenesis
			protein folding
			protein modification process
		cellular component	cytoplasm
			cytoskeleton
			microtubule
		molecular function	chaperone binding
			protein binding
ubiquilin-like [RefSeq_peptide;Acc:NP_659490]	2.75593	biological process	protein modification process
Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]	1.59763
			ubiquitin cycle
		cellular component	cytoplasm
		molecular function	ATP binding
			ligase activity
			nucleotide binding
			small conjugating protein ligase activity
			ubiquitin-protein ligase activity
Uncharacterized protein C17orf56. [Uniprot/SWISSPROT;Acc:Q96N21]	4.21401	cellular component	membrane
Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]	1.80942		integral to membrane
			membrane
Uncharacterized protein C20orf142 precursor. [Uniprot/SWISSPROT;Acc:Q8N6M3]	2.85383		integral to membrane
			membrane
WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904]	1.54676	biological process	cell adhesion

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.