MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Gene Ontology	Class	Regulation	description	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1043 to 1092 of 2667 in total

Ratio	Gene Ontology	Class	Regulation	description
1.43088	isomerase activity	molecular function	down	Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]
	isopentenyl-diphosphate delta-isomerase activity
	isoprenoid biosynthetic process	biological process
	magnesium ion binding	molecular function
	peroxisome	cellular component
1.43351	carboxypeptidase A activity	molecular function		Carboxypeptidase A2 precursor (EC 3.4.17.15). [Uniprot/SWISSPROT;Acc:P48052]
	carboxypeptidase activity
	metal ion binding
	metallopeptidase activity
	proteolysis	biological process
	vacuolar protein catabolic process
	zinc ion binding	molecular function
1.44004	extracellular space	cellular component		Cytokine-like protein 1 precursor (Protein C17). [Uniprot/SWISSPROT;Acc:Q9NRR1]
	receptor binding	molecular function
	signal transduction	biological process
	soluble fraction	cellular component
1.44789	DNA binding	molecular function	up	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B). [Uniprot/SWISSPROT;Acc:Q16633]
	humoral immune response	biological process
	nucleus	cellular component
	protein binding	molecular function
	regulation of transcription, DNA-dependent	biological process
	transcription
	transcription coactivator activity	molecular function
	transcription from RNA polymerase II promoter	biological process
1.45148	DNA binding	molecular function		Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372). [Uniprot/SWISSPROT;Acc:Q14789]
	ER-Golgi intermediate compartment	cellular component
	Golgi apparatus
	Golgi membrane
	Golgi organization and biogenesis	biological process
	Golgi stack	cellular component
	integral to membrane
	membrane
	nucleus
	protein binding	molecular function
	regulation of transcription, DNA-dependent	biological process
	vesicle-mediated transport
1.45314	DNA binding	molecular function		NULL
1.45624	circulation	biological process		Transcription factor NF-E2 45 kDa subunit (Nuclear factor, erythroid- derived 2 45 kDa subunit) (p45 NF-E2) (Leucine zipper protein NF-E2). [Uniprot/SWISSPROT;Acc:Q16621]
	DNA binding	molecular function
	hemostasis	biological process
	multicellular organismal development
	nucleus	cellular component
	protein dimerization activity	molecular function
	regulation of transcription	biological process
	regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	sequence-specific DNA binding	molecular function
	transcription coactivator activity
	transcription factor activity
1.45635	cell cycle	biological process		Cyclin-A2 (Cyclin-A). [Uniprot/SWISSPROT;Acc:P20248]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.