MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Regulation	Class	Gene Ontology	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1001 to 1050 of 2667 in total

description	Ratio	Regulation	Class	Gene Ontology
Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Uniprot/SWISSPROT;Acc:O75343]	1.18489	up	molecular function	guanylate cyclase activity
				heme binding
				iron ion binding
				metal ion binding
				phosphorus-oxygen lyase activity
Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	1.1611	down	biological process	electron transport
				signal transduction
			cellular component	extracellular region
			molecular function	electron carrier activity
				enzyme activator activity
				guanylate cyclase activator activity
				hormone activity
Hematological and neurological expressed 1 protein (Androgen-regulated protein 2). [Uniprot/SWISSPROT;Acc:Q9UK76]	3.62109		cellular component	nucleus
Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]	2.2939	up	biological process	organelle organization and biogenesis
				pigmentation
			cellular component	cytoplasm
Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]	1.27461	down	biological process	anatomical structure morphogenesis
				G-protein coupled receptor protein signaling pathway
				multicellular organismal development
				regulation of transcription, DNA-dependent
				thyroid gland development
			cellular component	integral to membrane
				nucleus
			molecular function	DNA binding
				galanin receptor activity
				sequence-specific DNA binding
				transcription factor activity
Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Uniprot/SWISSPROT;Acc:O15522]	1.30407	up	biological process	axonogenesis
				multicellular organismal development
				regulation of transcription, DNA-dependent
				transcription from RNA polymerase II promoter
			cellular component	nucleus
			molecular function	RNA polymerase II transcription factor activity
				sequence-specific DNA binding
				transcription factor activity
Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]	3.70292		biological process	anatomical structure development
				embryonic skeletal morphogenesis
				homoiothermy
				inner ear morphogenesis
				multicellular organismal development
				myoblast migration
				positive regulation of transcription
				regulation of transcription, DNA-dependent
				response to freezing
				striated muscle development
				thymus development
			cellular component	nucleus
			molecular function	ice binding
				sequence-specific DNA binding
				transcription factor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.