MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	description	Regulation	Gene	Class	Gene Ontology	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1001 to 1050 of 2667 in total

Ratio	description	Regulation	Class	Gene Ontology
1.40749	collagen, type XXVII, alpha 1 [RefSeq_peptide;Acc:NP_116277]	up	cellular component	integral to membrane
			molecular function	dopamine receptor activity
				extracellular matrix structural constituent
				structural constituent of cell wall
				structural molecule activity
1.41851	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]	down	biological process	MAPKKK cascade
				nervous system development
				transmembrane receptor protein tyrosine kinase signaling pathway
			molecular function	insulin receptor binding
				transmembrane receptor protein tyrosine kinase signaling protein activity
1.42215	Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Uniprot/SWISSPROT;Acc:P31645]		biological process	monoamine transport
				neurotransmitter transport
				neurotransmitter uptake
				serotonin transport
			cellular component	integral to plasma membrane
				membrane
			molecular function	monoamine transporter activity
				neurotransmitter:sodium symporter activity
				protein binding
				serotonin transporter activity
				serotonin:sodium symporter activity
				symporter activity
1.42264	RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Uniprot/SWISSPROT;Acc:Q9BWF3]	up	biological process	homoiothermy
				mRNA processing
				response to freezing
				RNA splicing
				translation
				type I hypersensitivity
			cellular component	cytoplasm
				intracellular
				nucleus
				ribosome
			molecular function	ice binding
				metal ion binding
				nucleic acid binding
				nucleotide binding
				RNA binding
				structural constituent of ribosome
				zinc ion binding
1.43088	Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]	down	biological process	carotenoid biosynthetic process
				cholesterol biosynthetic process
				isoprenoid biosynthetic process
			cellular component	peroxisome
			molecular function	hydrolase activity
				isomerase activity
				isopentenyl-diphosphate delta-isomerase activity
				magnesium ion binding
1.43351	Carboxypeptidase A2 precursor (EC 3.4.17.15). [Uniprot/SWISSPROT;Acc:P48052]		biological process	proteolysis
				vacuolar protein catabolic process
			molecular function	carboxypeptidase A activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.