MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Regulation	Ratio	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1001 to 1050 of 2667 in total

description	Regulation	Ratio	Gene Ontology	Class
Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2). [Uniprot/SWISSPROT;Acc:O75343]	up	1.18489	heme binding	molecular function
			intracellular signaling cascade	biological process
			iron ion binding	molecular function
			metal ion binding
			phosphorus-oxygen lyase activity
Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	down	1.1611	electron carrier activity
			electron transport	biological process
			enzyme activator activity	molecular function
			extracellular region	cellular component
			guanylate cyclase activator activity	molecular function
			hormone activity
			signal transduction	biological process
Hematological and neurological expressed 1 protein (Androgen-regulated protein 2). [Uniprot/SWISSPROT;Acc:Q9UK76]		3.62109	nucleus	cellular component
Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]	up	2.2939	cytoplasm
			organelle organization and biogenesis	biological process
			pigmentation
Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]	down	1.27461	anatomical structure morphogenesis
			DNA binding	molecular function
			G-protein coupled receptor protein signaling pathway	biological process
			galanin receptor activity	molecular function
			integral to membrane	cellular component
			multicellular organismal development	biological process
			nucleus	cellular component
			regulation of transcription, DNA-dependent	biological process
			sequence-specific DNA binding	molecular function
			thyroid gland development	biological process
			transcription factor activity	molecular function
Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H). [Uniprot/SWISSPROT;Acc:O15522]	up	1.30407	axonogenesis	biological process
			multicellular organismal development
			nucleus	cellular component
			regulation of transcription, DNA-dependent	biological process
			RNA polymerase II transcription factor activity	molecular function
			sequence-specific DNA binding
			transcription factor activity
			transcription from RNA polymerase II promoter	biological process
Homeobox protein SIX4 (Sine oculis homeobox homolog 4). [Uniprot/SWISSPROT;Acc:Q9UIU6]		3.70292	anatomical structure development
			embryonic skeletal morphogenesis
			homoiothermy
			ice binding	molecular function
			inner ear morphogenesis	biological process
			multicellular organismal development
			myoblast migration
			nucleus	cellular component
			positive regulation of transcription	biological process
			regulation of transcription, DNA-dependent
			response to freezing
			sequence-specific DNA binding	molecular function
			striated muscle development	biological process
			thymus development
			transcription factor activity	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.