MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Gene Ontology	Regulation	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2501 to 2550 of 2667 in total

description	Ratio	Gene Ontology	Regulation	Class
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20). [Uniprot/SWISSPROT;Acc:Q15696]	1.07618	nucleotide binding	up	molecular function
		nucleus		cellular component
		rhodopsin-like receptor activity		molecular function
		ribonucleoprotein complex		cellular component
		RNA binding		molecular function
		RNA splicing		biological process
		U12-dependent spliceosome		cellular component
		zinc ion binding		molecular function
ubiquilin-like [RefSeq_peptide;Acc:NP_659490]	2.75593	protein modification process	down	biological process
Ubiquitin-activating enzyme E1 domain-containing protein 1 (UFM1- activating enzyme) (Ubiquitin-activating enzyme 5) (ThiFP1). [Uniprot/SWISSPROT;Acc:Q9GZZ9]	8.21788	catalytic activity	up	molecular function
		cofactor binding
		cytoplasm		cellular component
		defense response		biological process
		DNA binding		molecular function
		humoral immune response		biological process
		nucleus		cellular component
		oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor		molecular function
		translation regulator activity
		ubiquitin cycle		biological process
Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]	1.59763	ATP binding	down	molecular function
		cytoplasm		cellular component
		ligase activity		molecular function
		nucleotide binding
		protein modification process		biological process
		small conjugating protein ligase activity		molecular function
		ubiquitin cycle		biological process
		ubiquitin-protein ligase activity		molecular function
Ubiquitin-conjugating enzyme E2 R2 (EC 6.3.2.19) (Ubiquitin-protein ligase R2) (Ubiquitin carrier protein R2) (E2-CDC34B). [Uniprot/SWISSPROT;Acc:Q712K3]	1.49444	ligase activity	up
		protein modification process		biological process
		small conjugating protein ligase activity		molecular function
		ubiquitin cycle		biological process
		ubiquitin-protein ligase activity		molecular function
Ufm1-specific protease 2 (EC 3.4.22.-) (UfSP2). [Uniprot/SWISSPROT;Acc:Q9NUQ7]	5.01332	cysteine-type peptidase activity
		thiolester hydrolase activity
		ubiquitin cycle		biological process
Uncharacterized protein C16orf48. [Uniprot/SWISSPROT;Acc:Q9H0I2]	1.27516	microtubule cytoskeleton		cellular component
Uncharacterized protein C17orf56. [Uniprot/SWISSPROT;Acc:Q96N21]	4.21401	membrane	down
Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]	1.80942	integral to membrane
		membrane
Uncharacterized protein C20orf142 precursor. [Uniprot/SWISSPROT;Acc:Q8N6M3]	2.85383	integral to membrane
		membrane
Uncharacterized protein C2orf29. [Uniprot/SWISSPROT;Acc:Q9UKZ1]	4.1026	cell proliferation	up	biological process
		cellular_component		cellular component
		molecular_function		molecular function
Uncharacterized protein C9orf117. [Uniprot/SPTREMBL;Acc:Q5JU67]	1.65422	intracellular		cellular component
		signal transduction		biological process
Voltage-dependent calcium channel gamma-7 subunit (Neuronal voltage- gated calcium channel gamma-7 subunit). [Uniprot/SWISSPROT;Acc:P62955]	3.41415	calcium ion binding		molecular function
		calcium ion transport		biological process
		integral to membrane		cellular component
		ion transport		biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.