MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2051 to 2100 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
2.87038	up	Calpain-3 (EC 3.4.22.54) (Calpain L3) (Calpain p94) (Calcium-activated neutral proteinase 3) (CANP 3) (Muscle-specific calcium-activated neutral protease 3) (nCL-1). [Uniprot/SWISSPROT;Acc:P20807]	molecular function	protein binding
				signal transducer activity
2.88128	down	CD302 antigen precursor (C-type lectin domain family 13 member A) (C- type lectin BIMLEC) (Type I transmembrane C-type lectin receptor DCL- 1). [Uniprot/SWISSPROT;Acc:Q8IX05]	cellular component	integral to membrane
				membrane
			molecular function	sugar binding
2.88235		Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]	biological process	anion transport
			cellular component	integral to membrane
				integral to plasma membrane
				membrane
				membrane fraction
			molecular function	anion exchanger activity
				antiporter activity
				inorganic anion exchanger activity
2.91954	up	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18). [Uniprot/SWISSPROT;Acc:O95232]	biological process	apoptosis
				response to stress
				RNA splicing
			cellular component	nucleus
			molecular function	DNA binding
				protein binding
2.93895	down	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Uniprot/SWISSPROT;Acc:Q92844]	biological process	I-kappaB kinase/NF-kappaB cascade
				signal transduction
			cellular component	cytoplasm
			molecular function	metal ion binding
				protein binding
				zinc ion binding
2.95579	up	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (hSSH-3L). [Uniprot/SWISSPROT;Acc:Q8TE77]	biological process	dephosphorylation
				protein amino acid dephosphorylation
			cellular component	cytoplasm
				cytoskeleton
				nucleus
			molecular function	hydrolase activity
				phosphoric monoester hydrolase activity
				protein tyrosine phosphatase activity
				protein tyrosine/serine/threonine phosphatase activity
2.96739		Protein FRA10AC1. [Uniprot/SWISSPROT;Acc:Q70Z53]	cellular component	nucleus
			molecular function	protein binding
3.00923	down	Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N- acetyltransferase type 1) (NAT-1). [Uniprot/SWISSPROT;Acc:P18440]	biological process	metabolic process
			cellular component	cytoplasm
			molecular function	acetyltransferase activity
				arylamine N-acetyltransferase activity
				transferase activity
3.03423	up	Suppressor of G2 allele of SKP1 homolog (Sgt1) (Putative 40-6-3 protein). [Uniprot/SWISSPROT;Acc:Q9Y2Z0]	biological process	mitosis
				regulation of progression through cell cycle
				ubiquitin cycle
			cellular component	kinetochore
				ubiquitin ligase complex
			molecular function	binding
3.05037	down	Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]	biological process	cell adhesion
				substrate-bound cell migration, cell extension
			cellular component	extracellular region

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.