MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Gene Ontology	Regulation	Accession	description	Class	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 983 to 1032 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
1.40552	neurotransmitter:sodium symporter activity	down	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76]	molecular function
	sodium:dicarboxylate symporter activity
	symporter activity
1.40602	cytoplasm	up	GTP-binding protein SAR1a (COPII-associated small GTPase). [Uniprot/SWISSPROT;Acc:Q9NR31]	cellular component
	endoplasmic reticulum
	ER to Golgi vesicle-mediated transport			biological process
	Golgi apparatus			cellular component
	GTP binding			molecular function
	GTPase activity
	intracellular			cellular component
	intracellular protein transport			biological process
	nucleotide binding			molecular function
	small GTPase mediated signal transduction			biological process
1.40749	cell adhesion		collagen, type XXVII, alpha 1 [RefSeq_peptide;Acc:NP_116277]
	collagen			cellular component
	cytoplasm
	dopamine receptor activity			molecular function
	extracellular matrix structural constituent
	G-protein coupled receptor protein signaling pathway			biological process
	integral to membrane			cellular component
	phosphate transport			biological process
	structural constituent of cell wall			molecular function
	structural molecule activity
1.41851	insulin receptor binding	down	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]
	MAPKKK cascade			biological process
	nervous system development
	transmembrane receptor protein tyrosine kinase signaling pathway
	transmembrane receptor protein tyrosine kinase signaling protein activity			molecular function
1.42215	integral to plasma membrane		Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Uniprot/SWISSPROT;Acc:P31645]	cellular component
	membrane
	monoamine transport			biological process
	monoamine transporter activity			molecular function
	neurotransmitter transport			biological process
	neurotransmitter uptake
	neurotransmitter:sodium symporter activity			molecular function
	protein binding
	serotonin transport			biological process
	serotonin transporter activity			molecular function
	serotonin:sodium symporter activity
	symporter activity
1.42264	cytoplasm	up	RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Uniprot/SWISSPROT;Acc:Q9BWF3]	cellular component
	homoiothermy			biological process
	ice binding			molecular function
	intracellular			cellular component
	metal ion binding			molecular function
	mRNA processing			biological process
	nucleic acid binding			molecular function
	nucleotide binding
	nucleus			cellular component
	response to freezing			biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.