Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Regulation Gene Ontology Ratio description Class Gene Accession Minimum Ratio Maximum Ratio
Results: HTML CSV LaTeX Showing element 951 to 1000 of 2667 in total
Regulation  : down
Gene Ontology
Ratio
description
Class
rhodopsin-like receptor activity 1.36911 Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). [Uniprot/SWISSPROT;Acc:Q96P65] molecular function
3.52215 Olfactory receptor 4L1 (Olfactory receptor OR14-28). [Uniprot/SWISSPROT;Acc:Q8NH43]
ribonuclease activity 1.683 Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]
2.12709 Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]
ribonuclease MRP complex cellular component
ribonuclease P activity molecular function
ribonuclease P complex cellular component
ribonucleoprotein complex 2.61135 28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Uniprot/SWISSPROT;Acc:P82673]
ribosome 2.16131 39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Uniprot/SWISSPROT;Acc:Q9P015]
2.45383 40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]
RNA binding 1.25205 Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013] molecular function
1.683 Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]
2.12709 Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]
2.45383 40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]
RNA polymerase II transcription factor activity, enhancer binding 3.29064 Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]
RNA polymerase II transcription mediator activity 1.30082 CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). [Uniprot/SWISSPROT;Acc:Q9NZN8]
RNA splicing 1.25205 Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013] biological process
3.43019 Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). [Uniprot/SWISSPROT;Acc:O95926]
rRNA processing 1.683 Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]
2.12709 Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]
sarcoplasmic reticulum 3.39764 Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5] cellular component
SCF ubiquitin ligase complex 2.33107 F-box only protein 15. [Uniprot/SWISSPROT;Acc:Q8NCQ5]
selenocysteine incorporation 1.65835 Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772] biological process
sensory perception of pain 3.27919 Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]
sensory perception of smell 3.52215 Olfactory receptor 4L1 (Olfactory receptor OR14-28). [Uniprot/SWISSPROT;Acc:Q8NH43]
sensory perception of sound 1.30142 Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607]
sequence-specific DNA binding 1.27461 Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249] molecular function
1.28356 T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207]
1.98137 Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]
3.29064 Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]
3.48313 Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Uniprot/SWISSPROT;Acc:Q9GZN2]
4.4149 X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5). [Uniprot/SWISSPROT;Acc:P17861]
serine-type endopeptidase inhibitor activity 2.08208 Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]
serotonin transport 1.42215 Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Uniprot/SWISSPROT;Acc:P31645] biological process
serotonin transporter activity molecular function
serotonin:sodium symporter activity
sexual reproduction 1.20481 Neurosecretory protein VGF precursor. [Uniprot/SWISSPROT;Acc:O15240] biological process
sialyltransferase activity 1.69658 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206] molecular function
signal transducer activity 2.44552 Guanine nucleotide-binding protein alpha-14 subunit (G-protein alpha subunit 14). [Uniprot/SWISSPROT;Acc:O95837]
3.54799 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]
signal transduction 1.1611 Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747] biological process
1.18821 Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Uniprot/SWISSPROT;Acc:P32927]
1.19212 Thyroglobulin precursor. [Uniprot/SWISSPROT;Acc:P01266]
1.23783 Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Uniprot/SWISSPROT;Acc:Q8WZ64]
1.24114 Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]
1.36911 Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). [Uniprot/SWISSPROT;Acc:Q96P65]
1.44004 Cytokine-like protein 1 precursor (Protein C17). [Uniprot/SWISSPROT;Acc:Q9NRR1]
1.49923 Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]
1.5415 Pleckstrin homology-like domain family B member 2 (Protein LL5-beta). [Uniprot/SWISSPROT;Acc:Q86SQ0]
1.61347 Calmodulin-like protein 5 (Calmodulin-like skin protein). [Uniprot/SWISSPROT;Acc:Q9NZT1]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/