MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 951 to 1000 of 2667 in total

Regulation  : down

Ratio	Gene Ontology	description	Class
3.29064	positive regulation of transcription	Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]	biological process
	positive regulation of transcription from RNA polymerase II promoter
	protein binding		molecular function
	regulation of transcription, DNA-dependent		biological process
	RNA polymerase II transcription factor activity, enhancer binding		molecular function
	sequence-specific DNA binding
	transcription		biological process
	transcription factor activity		molecular function
	transcriptional activator activity
	zinc ion binding
3.39764	biological_process	Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5]	biological process
	integral to membrane		cellular component
	junctional membrane complex
	membrane
	microsome
	molecular_function		molecular function
	muscle development		biological process
	sarcoplasmic reticulum		cellular component
	structural constituent of muscle		molecular function
	Z disc		cellular component
3.43019	biological_process	Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). [Uniprot/SWISSPROT;Acc:O95926]	biological process
	mRNA processing
	nucleus		cellular component
	protein binding		molecular function
	RNA splicing		biological process
	spliceosome		cellular component
3.48313	nucleus	Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Uniprot/SWISSPROT;Acc:Q9GZN2]
	regulation of transcription, DNA-dependent		biological process
	sequence-specific DNA binding		molecular function
	transcription factor activity
3.52215	G-protein coupled receptor protein signaling pathway	Olfactory receptor 4L1 (Olfactory receptor OR14-28). [Uniprot/SWISSPROT;Acc:Q8NH43]	biological process
	integral to membrane		cellular component
	melanocortin receptor activity		molecular function
	membrane		cellular component
	olfactory receptor activity		molecular function
	receptor activity
	response to stimulus		biological process
	rhodopsin-like receptor activity		molecular function
	sensory perception of smell		biological process
	signal transduction
3.54799	calcium channel regulator activity	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]	molecular function
	G-protein coupled receptor protein signaling pathway		biological process
	GTPase activity		molecular function
	protein binding
	signal transducer activity
	signal transduction		biological process
3.54928	cytoplasm	Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2). [Uniprot/SWISSPROT;Acc:Q8WTR4]	cellular component
	glycerol metabolic process		biological process
	glycerophosphodiester phosphodiesterase activity		molecular function
	hydrolase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.