MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Accession	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 951 to 1000 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
3.29064	Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]	cellular component	nucleus
		molecular function	chromatin binding
			DNA binding
			metal ion binding
			protein binding
			RNA polymerase II transcription factor activity, enhancer binding
			sequence-specific DNA binding
			transcription factor activity
			transcriptional activator activity
			zinc ion binding
3.39764	Junctophilin-1 (Junctophilin type 1) (JP-1). [Uniprot/SWISSPROT;Acc:Q9HDC5]	biological process	biological_process
			muscle development
		cellular component	integral to membrane
			junctional membrane complex
			membrane
			microsome
			sarcoplasmic reticulum
			Z disc
		molecular function	molecular_function
			structural constituent of muscle
3.43019	Pre-mRNA-splicing factor SYF2 (CCNDBP1-interactor) (p29). [Uniprot/SWISSPROT;Acc:O95926]	biological process	biological_process
			mRNA processing
			RNA splicing
		cellular component	nucleus
			spliceosome
		molecular function	protein binding
3.48313	Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Uniprot/SWISSPROT;Acc:Q9GZN2]	biological process	regulation of transcription, DNA-dependent
		cellular component	nucleus
		molecular function	sequence-specific DNA binding
			transcription factor activity
3.52215	Olfactory receptor 4L1 (Olfactory receptor OR14-28). [Uniprot/SWISSPROT;Acc:Q8NH43]	biological process	G-protein coupled receptor protein signaling pathway
			response to stimulus
			sensory perception of smell
			signal transduction
		cellular component	integral to membrane
			membrane
		molecular function	melanocortin receptor activity
			olfactory receptor activity
			receptor activity
			rhodopsin-like receptor activity
3.54799	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]	biological process	G-protein coupled receptor protein signaling pathway
			signal transduction
		molecular function	calcium channel regulator activity
			GTPase activity
			protein binding
			signal transducer activity
3.54928	Glycerophosphodiester phosphodiesterase domain-containing protein 5 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 2). [Uniprot/SWISSPROT;Acc:Q8WTR4]	biological process	glycerol metabolic process
		cellular component	cytoplasm
			integral to membrane
			membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.