MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 905 to 954 of 2667 in total

Regulation  : down

Ratio	Gene Ontology	description	Class
3.06659	nucleotide binding	ATP-binding domain 1 family member B. [Uniprot/SWISSPROT;Acc:Q9H9Y4]	molecular function
3.07625	cell motility	Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). [Uniprot/SWISSPROT;Acc:O60637]	biological process
	cell proliferation
	integral to membrane		cellular component
	membrane
3.11758	cytokine activity	Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]	molecular function
	extracellular region		cellular component
	extracellular space
	growth		biological process
	growth factor activity		molecular function
3.15011	calcium ion binding	Ninein-like protein. [Uniprot/SWISSPROT;Acc:Q9Y2I6]
	cytoplasm		cellular component
	microtubule
3.27919	apoptosis	Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]	biological process
	behavior
	calcium ion binding		molecular function
	calcium-dependent protein binding
	cytoplasm		cellular component
	cytosol
	DNA binding		molecular function
	endoplasmic reticulum		cellular component
	Golgi apparatus
	ion channel activity		molecular function
	ion transport		biological process
	membrane		cellular component
	negative regulation of transcription from RNA polymerase II promoter		biological process
	nucleus		cellular component
	potassium channel activity		molecular function
	potassium ion binding
	potassium ion transport		biological process
	protein C-terminus binding		molecular function
	regulation of neuron apoptosis		biological process
	regulation of transcription from RNA polymerase II promoter
	response to pain
	sensory perception of pain
	signal transduction
	specific transcriptional repressor activity		molecular function
	transcription		biological process
	transcription corepressor activity		molecular function
	voltage-gated ion channel activity
3.29064	chromatin binding	Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]
	DNA binding
	liver development		biological process
	metal ion binding		molecular function
	muscle development		biological process
	nucleus		cellular component
	positive regulation of transcription		biological process
	positive regulation of transcription from RNA polymerase II promoter
	protein binding		molecular function
	regulation of transcription, DNA-dependent		biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.