MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Class	description	Gene Ontology	Accession	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 905 to 954 of 2667 in total

Regulation  : down

Ratio	Class	description	Gene Ontology
3.06659	molecular function	ATP-binding domain 1 family member B. [Uniprot/SWISSPROT;Acc:Q9H9Y4]	nucleotide binding
3.07625	biological process	Tetraspanin-3 (Tspan-3) (Transmembrane 4 superfamily member 8) (Tetraspanin TM4-A). [Uniprot/SWISSPROT;Acc:O60637]	cell motility
			cell proliferation
	cellular component		integral to membrane
			membrane
3.11758	biological process	Growth/differentiation factor 2 precursor (GDF-2) (Bone morphogenetic protein 9) (BMP-9). [Uniprot/SWISSPROT;Acc:Q9UK05]	growth
	cellular component		extracellular region
			extracellular space
	molecular function		cytokine activity
			growth factor activity
3.15011	cellular component	Ninein-like protein. [Uniprot/SWISSPROT;Acc:Q9Y2I6]	cytoplasm
			microtubule
	molecular function		calcium ion binding
3.27919	biological process	Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7]	apoptosis
			behavior
			ion transport
			negative regulation of transcription from RNA polymerase II promoter
			potassium ion transport
			regulation of neuron apoptosis
			regulation of transcription from RNA polymerase II promoter
			response to pain
			sensory perception of pain
			signal transduction
			transcription
	cellular component		cytoplasm
			cytosol
			endoplasmic reticulum
			Golgi apparatus
			membrane
			nucleus
	molecular function		calcium ion binding
			calcium-dependent protein binding
			DNA binding
			ion channel activity
			potassium channel activity
			potassium ion binding
			protein C-terminus binding
			specific transcriptional repressor activity
			transcription corepressor activity
			voltage-gated ion channel activity
3.29064	biological process	Transcription factor GATA-6 (GATA-binding factor 6). [Uniprot/SWISSPROT;Acc:Q92908]	liver development
			muscle development
			positive regulation of transcription
			positive regulation of transcription from RNA polymerase II promoter
			regulation of transcription, DNA-dependent
			transcription
	cellular component		nucleus
	molecular function		chromatin binding
			DNA binding
			metal ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.