MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Ratio	Accession	Regulation	Gene Ontology	description	Class	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 901 to 950 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
1.35022	up	endonuclease activity	N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527]	molecular function
		hydrolase activity, acting on glycosyl bonds
		intracellular		cellular component
		lyase activity		molecular function
		metabolic process		biological process
		microtubule binding		molecular function
		mitochondrion		cellular component
		nucleoplasm
		nucleus
		oxidized purine base lesion DNA N-glycosylase activity		molecular function
		protein binding
1.351	down	dopamine receptor activity	TBK1 binding protein 1 [RefSeq_peptide;Acc:NP_055541]
		G-protein coupled receptor protein signaling pathway		biological process
		integral to membrane		cellular component
1.35125	up	cell cycle	Geminin. [Uniprot/SWISSPROT;Acc:O75496]	biological process
		negative regulation of DNA replication
		negative regulation of progression through cell cycle
		nucleus		cellular component
		organ morphogenesis		biological process
		protein binding		molecular function
		regulation of progression through cell cycle		biological process
1.36349	down		Cyclin-I. [Uniprot/SWISSPROT;Acc:Q14094]
		spermatogenesis
1.36755		biological_process	Nucleolar preribosomal-associated protein 1 (Fragment). [Uniprot/SWISSPROT;Acc:O60287]
		molecular_function		molecular function
		nucleolus		cellular component
		nucleus
1.36911		bombesin receptor activity	Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). [Uniprot/SWISSPROT;Acc:Q96P65]	molecular function
		G-protein coupled receptor protein signaling pathway		biological process
		integral to membrane		cellular component
		membrane
		metabotropic glutamate, GABA-B-like receptor activity		molecular function
		neuropeptide receptor activity
		neuropeptide Y receptor activity
		orexin receptor activity
		purinergic nucleotide receptor activity, G-protein coupled
		receptor activity
		rhodopsin-like receptor activity
		signal transduction		biological process
1.36997	up	angiogenesis	Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73 kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Sarcoma antigen NY-SAR-88). [Uniprot/SWISSPROT;Acc:Q8N264]
		cell differentiation
		cell junction		cellular component
		cytoplasm
		cytoskeleton
		GTPase activator activity		molecular function
		intracellular		cellular component
		membrane
		multicellular organismal development		biological process
		protein binding		molecular function
		signal transduction		biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.