MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 855 to 904 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.33465	up	T-box transcription factor TBX5 (T-box protein 5). [Uniprot/SWISSPROT;Acc:Q99593]	biological process	pericardium development
				positive regulation of cardioblast differentiation
				positive regulation of transcription from RNA polymerase II promoter
				positive regulation of transcription, DNA-dependent
				regulation of transcription, DNA-dependent
				transcription
			cellular component	cytoplasm
				nucleus
			molecular function	protein binding
				RNA polymerase II transcription factor activity
				sequence-specific DNA binding
				transcription factor activity
				transcriptional activator activity
1.33817	down	Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) (Early estrogen-regulated protein). [Uniprot/SWISSPROT;Acc:Q9H0R8]	biological process	autophagic vacuole formation
			cellular component	autophagic vacuole
				cytoplasm
				intracellular
				microtubule
			molecular function	beta-tubulin binding
				GABA receptor binding
				protein binding
1.34001	up	Protein DmX-like 2 (Rabconnectin-3). [Uniprot/SWISSPROT;Acc:Q8TDJ6]	cellular component	cell junction
				cytoplasmic vesicle
				membrane
				synapse
				synaptic vesicle
			molecular function	Rab GTPase binding
1.34491		Bardet-Biedl syndrome 5 protein. [Uniprot/SWISSPROT;Acc:Q8N3I7]	biological process	response to stimulus
				visual perception
			cellular component	cellular_component
				cilium
				intracellular
			molecular function	molecular_function
1.34969		MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10). [Uniprot/SWISSPROT;Acc:P27448]	biological process	protein amino acid phosphorylation
			molecular function	ATP binding
				nucleotide binding
				protein binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
1.35022		N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527]	biological process	base-excision repair
				DNA repair
				metabolic process
			cellular component	cellular_component
				intracellular
				mitochondrion
				nucleoplasm
				nucleus
			molecular function	damaged DNA binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.