MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 855 to 904 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
2.61135	28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Uniprot/SWISSPROT;Acc:P82673]	DNA damage response, detection of DNA damage	biological process
		mitochondrial small ribosomal subunit	cellular component
		mitochondrion
		peptide biosynthetic process	biological process
		ribonucleoprotein complex	cellular component
2.75593	ubiquilin-like [RefSeq_peptide;Acc:NP_659490]	protein modification process	biological process
2.79087	leucine-rich repeat neuronal 6A [RefSeq_peptide;Acc:NP_116197]	defense response
		integral to membrane	cellular component
		membrane
		protein binding	molecular function
2.83611	SERTA domain-containing protein 3 (Replication protein-binding trans- activator) (RPA-binding trans-activator). [Uniprot/SWISSPROT;Acc:Q9UJW9]	negative regulation of cell growth	biological process
		nucleus	cellular component
		positive regulation of transcription	biological process
		protein binding	molecular function
		regulation of transcription, DNA-dependent	biological process
		transcription
		transcriptional activator activity	molecular function
2.85383	Uncharacterized protein C20orf142 precursor. [Uniprot/SWISSPROT;Acc:Q8N6M3]	integral to membrane	cellular component
		membrane
2.88128	CD302 antigen precursor (C-type lectin domain family 13 member A) (C- type lectin BIMLEC) (Type I transmembrane C-type lectin receptor DCL- 1). [Uniprot/SWISSPROT;Acc:Q8IX05]	integral to membrane
		membrane
		sugar binding	molecular function
2.88235	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751]	anion exchanger activity
		anion transport	biological process
		antiporter activity	molecular function
		inorganic anion exchanger activity
		integral to membrane	cellular component
		integral to plasma membrane
		membrane
		membrane fraction
2.93895	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF). [Uniprot/SWISSPROT;Acc:Q92844]	cytoplasm
		I-kappaB kinase/NF-kappaB cascade	biological process
		metal ion binding	molecular function
		protein binding
		signal transduction	biological process
		zinc ion binding	molecular function
3.00923	Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N- acetyltransferase type 1) (NAT-1). [Uniprot/SWISSPROT;Acc:P18440]	acetyltransferase activity
		arylamine N-acetyltransferase activity
		cytoplasm	cellular component
		metabolic process	biological process
		transferase activity	molecular function
3.05037	Thrombospondin-4 precursor. [Uniprot/SWISSPROT;Acc:P35443]	calcium ion binding
		cell adhesion	biological process
		extracellular region	cellular component
		heparin binding	molecular function
		protein binding
		proteinaceous extracellular matrix	cellular component
		structural molecule activity	molecular function
		substrate-bound cell migration, cell extension	biological process
3.06659	ATP-binding domain 1 family member B. [Uniprot/SWISSPROT;Acc:Q9H9Y4]	ATP binding	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.