MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Accession	Gene Ontology	Regulation	description	Minimum Ratio	Class	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 851 to 900 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
1.33465	morphogenesis of an epithelium	up	T-box transcription factor TBX5 (T-box protein 5). [Uniprot/SWISSPROT;Acc:Q99593]	biological process
	multicellular organismal development
	negative regulation of cardiac muscle cell proliferation
	negative regulation of cell migration
	nucleus			cellular component
	pattern specification process			biological process
	pericardium development
	positive regulation of cardioblast differentiation
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of transcription, DNA-dependent
	protein binding			molecular function
	regulation of transcription, DNA-dependent			biological process
	RNA polymerase II transcription factor activity			molecular function
	sequence-specific DNA binding
	transcription			biological process
	transcription factor activity			molecular function
	transcriptional activator activity
1.33817	autophagic vacuole	down	Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) (Early estrogen-regulated protein). [Uniprot/SWISSPROT;Acc:Q9H0R8]	cellular component
	autophagic vacuole formation			biological process
	beta-tubulin binding			molecular function
	cytoplasm			cellular component
	GABA receptor binding			molecular function
	intracellular			cellular component
	microtubule
	protein binding			molecular function
1.34001	cell junction	up	Protein DmX-like 2 (Rabconnectin-3). [Uniprot/SWISSPROT;Acc:Q8TDJ6]	cellular component
	cytoplasmic vesicle
	membrane
	Rab GTPase binding			molecular function
	synapse			cellular component
	synaptic vesicle
1.34491	cellular_component		Bardet-Biedl syndrome 5 protein. [Uniprot/SWISSPROT;Acc:Q8N3I7]
	cilium
	intracellular
	molecular_function			molecular function
	response to stimulus			biological process
	visual perception
1.34969	ATP binding		MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10). [Uniprot/SWISSPROT;Acc:P27448]	molecular function
	nucleotide binding
	protein amino acid phosphorylation			biological process
	protein binding			molecular function
	protein kinase activity
	protein serine/threonine kinase activity
	protein-tyrosine kinase activity
	transferase activity
1.35022	base-excision repair		N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527]	biological process
	cellular_component			cellular component
	damaged DNA binding			molecular function
	DNA binding
	DNA repair			biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.