MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Gene Ontology	Regulation	description	Accession	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 801 to 850 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
1.30869	mitotic checkpoint	down	E3 ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein) (RING finger protein 196). [Uniprot/SWISSPROT;Acc:Q96EP1]	biological process
	nucleus			cellular component
	protein binding			molecular function
	protein polyubiquitination			biological process
	ubiquitin cycle
	ubiquitin-dependent protein catabolic process
	ubiquitin-protein ligase activity			molecular function
	zinc ion binding
1.31489	intracellular		Tripartite motif-containing protein 58 (Protein BIA2). [Uniprot/SWISSPROT;Acc:Q8NG06]	cellular component
	metal ion binding			molecular function
	protein binding
	zinc ion binding
1.31661	anion exchanger activity	up	Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879]
	anion transport			biological process
	antiporter activity			molecular function
	apical plasma membrane			cellular component
	brush border membrane
	chloride ion binding			molecular function
	cytochrome complex assembly			biological process
	excretion
	heme transport
	heme transporter activity			molecular function
	integral to membrane			cellular component
	membrane
	membrane fraction
	sulfate porter activity			molecular function
	sulfate transport			biological process
	transcription cofactor activity			molecular function
	transcription factor activity
	transport			biological process
	transporter activity			molecular function
1.31895	receptor activity		Fc receptor-like 1 [RefSeq_peptide;Acc:NP_443170]
1.32602	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	down	CDNA: FLJ22222 fis, clone HRC01658. [Uniprot/SPTREMBL;Acc:Q9H6J2]
	protein metabolic process			biological process
1.33329	beta-mannosidase activity	up	Beta-mannosidase precursor (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase). [Uniprot/SWISSPROT;Acc:O00462]	molecular function
	carbohydrate metabolic process			biological process
	cation binding			molecular function
	glycoprotein catabolic process			biological process
	hydrolase activity, hydrolyzing O-glycosyl compounds			molecular function
	lysosome			cellular component
	metabolic process			biological process
	protein modification process
1.33465	cell-cell signaling		T-box transcription factor TBX5 (T-box protein 5). [Uniprot/SWISSPROT;Acc:Q99593]
	cytoplasm			cellular component
	embryonic arm morphogenesis			biological process
	embryonic limb morphogenesis
	forelimb morphogenesis
	heart development
	induction of apoptosis
	lung development

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.