MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 768 to 817 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.98137	Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]	molecular function	ligand-dependent nuclear receptor activity
			metal ion binding
			protein binding
			sequence-specific DNA binding
			steroid hormone receptor activity
			thyroid hormone receptor activity
			transcription factor activity
			zinc ion binding
2.08208	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]	biological process	hyaluronan metabolic process
		cellular component	extracellular region
		molecular function	serine-type endopeptidase inhibitor activity
2.11557	Echinoderm microtubule-associated protein-like 5 (EMAP-5). [Uniprot/SWISSPROT;Acc:Q05BV3]	cellular component	cytoplasm
			microtubule
2.12709	Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]	biological process	rRNA processing
			tRNA processing
		cellular component	nucleus
			ribonuclease MRP complex
			ribonuclease P complex
		molecular function	hydrolase activity
			identical protein binding
			ribonuclease activity
			ribonuclease P activity
			RNA binding
2.16131	39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Uniprot/SWISSPROT;Acc:Q9P015]	biological process	translation
		cellular component	intracellular
			large ribosomal subunit
			mitochondrion
			ribosome
		molecular function	structural constituent of ribosome
2.25955	Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92]	biological process	threonyl-tRNA aminoacylation
			translation
			tRNA aminoacylation for protein translation
		cellular component	cytoplasm
			mitochondrion
		molecular function	aminoacyl-tRNA ligase activity
			ATP binding
			ligase activity
			nucleotide binding
			threonine-tRNA ligase activity
2.27115	RIM-binding protein 2 (RIM-BP2). [Uniprot/SWISSPROT;Acc:O15034]	cellular component	cell junction
			membrane
			synapse
2.31699	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]	biological process	protein amino acid dephosphorylation
		cellular component	cytoplasm
			protein phosphatase type 2A complex
		molecular function	hydrolase activity
			iron ion binding
			manganese ion binding
			metal ion binding
			phosphoprotein phosphatase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.