MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Class	description	Gene Ontology	Accession	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 755 to 804 of 2667 in total

Regulation  : down

Ratio	Class	description	Gene Ontology
1.89168	cellular component	Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10). [Uniprot/SWISSPROT;Acc:O95125]	intracellular
			nucleus
	molecular function		DNA binding
			metal ion binding
			nucleic acid binding
			specific RNA polymerase II transcription factor activity
			transcription factor activity
			zinc ion binding
1.98137	biological process	Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]	regulation of transcription, DNA-dependent
			signal transduction
			transcription
	cellular component		nucleus
	molecular function		DNA binding
			ligand-dependent nuclear receptor activity
			metal ion binding
			protein binding
			sequence-specific DNA binding
			steroid hormone receptor activity
			thyroid hormone receptor activity
			transcription factor activity
			zinc ion binding
2.08208	biological process	Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]	hyaluronan metabolic process
	cellular component		extracellular region
	molecular function		serine-type endopeptidase inhibitor activity
2.11557	cellular component	Echinoderm microtubule-associated protein-like 5 (EMAP-5). [Uniprot/SWISSPROT;Acc:Q05BV3]	cytoplasm
			microtubule
2.12709	biological process	Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]	rRNA processing
			tRNA processing
	cellular component		nucleus
			ribonuclease MRP complex
			ribonuclease P complex
	molecular function		hydrolase activity
			identical protein binding
			ribonuclease activity
			ribonuclease P activity
			RNA binding
2.16131	biological process	39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Uniprot/SWISSPROT;Acc:Q9P015]	translation
	cellular component		intracellular
			large ribosomal subunit
			mitochondrion
			ribosome
	molecular function		structural constituent of ribosome
2.25955	biological process	Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92]	threonyl-tRNA aminoacylation
			translation
			tRNA aminoacylation for protein translation
	cellular component		cytoplasm
			mitochondrion
	molecular function		aminoacyl-tRNA ligase activity
			ATP binding
			ligase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.