MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 719 to 768 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
1.80858	Rhophilin-1 (GTP-Rho-binding protein 1). [Uniprot/SWISSPROT;Acc:Q8TCX5]	signal transduction	biological process
		small GTPase regulator activity	molecular function
1.80942	Uncharacterized protein C18orf26. [Uniprot/SWISSPROT;Acc:Q8N1N2]	integral to membrane	cellular component
		membrane
1.81557	Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1]	ATP binding	molecular function
		DNA binding
		helicase activity
		homoiothermy	biological process
		hydrolase activity	molecular function
		ice binding
		nucleic acid binding
		nucleotide binding
		nucleus	cellular component
		response to freezing	biological process
1.82063	Transmembrane protein 116. [Uniprot/SWISSPROT;Acc:Q8NCL8]	integral to membrane	cellular component
		membrane
1.82311	Fibroblast growth factor 5 precursor (FGF-5) (HBGF-5) (Smag-82). [Uniprot/SWISSPROT;Acc:P12034]	cell proliferation	biological process
		cell-cell signaling
		extracellular space	cellular component
		fibroblast growth factor receptor signaling pathway	biological process
		glial cell differentiation
		growth factor activity	molecular function
		nervous system development	biological process
		regulation of progression through cell cycle
1.86204	Zinc finger and SCAN domain-containing protein 4 (Zinc finger protein 494). [Uniprot/SWISSPROT;Acc:Q8NAM6]	intracellular	cellular component
		metal ion binding	molecular function
		nucleic acid binding
		nucleus	cellular component
		regulation of transcription, DNA-dependent	biological process
		transcription
		transcription factor activity	molecular function
		zinc ion binding
1.89168	Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10). [Uniprot/SWISSPROT;Acc:O95125]	DNA binding
		intracellular	cellular component
		lipid metabolic process	biological process
		metal ion binding	molecular function
		negative regulation of transcription from RNA polymerase II promoter	biological process
		nucleic acid binding	molecular function
		nucleus	cellular component
		regulation of transcription, DNA-dependent	biological process
		specific RNA polymerase II transcription factor activity	molecular function
		transcription	biological process
		transcription factor activity	molecular function
		zinc ion binding
1.98137	Nuclear receptor ROR-alpha (Retinoid-related orphan receptor-alpha) (Nuclear receptor RZR-alpha). [Uniprot/SWISSPROT;Acc:P35398]	DNA binding
		ligand-dependent nuclear receptor activity
		metal ion binding
		nucleus	cellular component
		protein binding	molecular function
		regulation of transcription, DNA-dependent	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.