MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 701 to 750 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.29238	up	Coiled-coil and C2 domain-containing protein 1B. [Uniprot/SWISSPROT;Acc:Q5T0F9]	oxidoreductase activity	molecular function
1.29424	down	Calcyphosin-2 (Calcyphosine-2). [Uniprot/SWISSPROT;Acc:Q9BXY5]	calcium ion binding
			ciliary or flagellar motility	biological process
			flagellin-based flagellum	cellular component
1.2984		nucleolar and spindle associated protein 1 isoform 2 [RefSeq_peptide;Acc:NP_060924]	cytokinesis after mitosis	biological process
			establishment of mitotic spindle localization
			microtubule binding	molecular function
			mitotic chromosome condensation	biological process
			nucleolus	cellular component
			positive regulation of mitosis	biological process
			spindle microtubule	cellular component
1.29952		Melanoma-associated antigen C2 (MAGE-C2 antigen) (MAGE-E1 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen 10) (CT10). [Uniprot/SWISSPROT;Acc:Q9UBF1]	cytoplasm
			nucleus
			regulation of progression through cell cycle	biological process
1.30082		CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). [Uniprot/SWISSPROT;Acc:Q9NZN8]	cytoplasm	cellular component
			nucleus
			regulation of global transcription from RNA polymerase II promoter	biological process
			regulation of transcription
			regulation of transcription, DNA-dependent
			RNA polymerase II transcription mediator activity	molecular function
			transcription regulator activity
1.30142		Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607]	ATP binding
			cell growth	biological process
			fibroblast growth factor receptor activity	molecular function
			fibroblast growth factor receptor signaling pathway	biological process
			forebrain development
			hair cell differentiation
			identical protein binding	molecular function
			inner ear development	biological process
			integral to membrane	cellular component
			integral to plasma membrane
			interleukin-1 receptor activity	molecular function
			internal side of plasma membrane	cellular component
			JAK-STAT cascade	biological process
			lysosome	cellular component
			MAPKKK cascade	biological process
			membrane	cellular component
			morphogenesis of an epithelium	biological process
			negative regulation of epithelial cell proliferation
			nucleotide binding	molecular function
			perinuclear region of cytoplasm	cellular component
			positive regulation of apoptosis	biological process
			positive regulation of cell differentiation
			positive regulation of peptidyl-tyrosine phosphorylation
			positive regulation of protein ubiquitination
			protein amino acid phosphorylation
			protein kinase activity	molecular function
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			receptor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.