MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Accession	Gene Ontology	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 68 to 117 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.12417	up	Protein CutA precursor (Brain acetylcholinesterase putative membrane anchor) (Acetylcholinesterase-associated protein). [Uniprot/SWISSPROT;Acc:O60888]	molecular function	thyroid hormone receptor coactivator activity
				vitamin D receptor binding
1.1243	down	Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]	biological process	regulation of transcription, DNA-dependent
				transcription
			cellular component	intracellular
				nucleus
			molecular function	DNA binding
				metal ion binding
				nucleic acid binding
				zinc ion binding
1.13007	up	Zinc finger protein 219. [Uniprot/SWISSPROT;Acc:Q9P2Y4]	biological process	anion transport
				G-protein coupled receptor protein signaling pathway
				regulation of transcription, DNA-dependent
			cellular component	integral to membrane
				intracellular
				membrane
				nucleus
			molecular function	histamine receptor activity
				inorganic anion exchanger activity
				metal ion binding
				nucleic acid binding
				transcription factor activity
				zinc ion binding
1.13541	down	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]	biological process	blood coagulation
				cell adhesion
				regulation of growth
			cellular component	extracellular region
				membrane
			molecular function	calcium ion binding
				protein binding
				structural molecule activity
				transmembrane receptor activity
1.14311		14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	biological process	negative regulation of protein kinase activity
				protein targeting
				regulation of neuron differentiation
				regulation of signal transduction
				regulation of synaptic plasticity
			cellular component	cytoplasm
			molecular function	insulin-like growth factor receptor binding
				protein domain specific binding
				protein kinase C binding
				protein kinase C inhibitor activity
1.14915	up	Transmembrane emp24 domain-containing protein 1 precursor (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor- binding protein). [Uniprot/SWISSPROT;Acc:Q13445]	biological process	cell-cell signaling
				signal transduction
				transport
			cellular component	integral to membrane
				membrane
			molecular function	receptor binding
1.15279		Podocalyxin-like protein 2 precursor (Endoglycan). [Uniprot/SWISSPROT;Acc:Q9NZ53]	biological process	cell adhesion
			cellular component	integral to plasma membrane

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.