MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 669 to 718 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.28514	up	EF-hand domain-containing protein C17orf57. [Uniprot/SWISSPROT;Acc:Q8IY85]	molecular function	calcium ion binding
1.28698		THO complex subunit 2 (Tho2). [Uniprot/SWISSPROT;Acc:Q8NI27]	biological process	mRNA processing
				mRNA transport
				RNA splicing
				transport
			cellular component	nucleus
			molecular function	RNA binding
1.28805	down	ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	biological process	proteolysis
			cellular component	extracellular matrix
				proteinaceous extracellular matrix
			molecular function	metal ion binding
				metalloendopeptidase activity
				metallopeptidase activity
				peptidase activity
				zinc ion binding
1.29151	up	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (hOrbit2). [Uniprot/SWISSPROT;Acc:O75122]	biological process	cell cycle
				cell division
				establishment and/or maintenance of cell polarity
				mitosis
				negative regulation of microtubule depolymerization
				regulation of microtubule polymerization or depolymerization
			cellular component	cytoplasm
				cytoplasmic microtubule
				cytoskeleton
				Golgi apparatus
				kinetochore microtubule
			molecular function	binding
				galactoside 2-alpha-L-fucosyltransferase activity
				microtubule binding
				microtubule plus-end binding
				protein binding
1.29238		Coiled-coil and C2 domain-containing protein 1B. [Uniprot/SWISSPROT;Acc:Q5T0F9]		FAD binding
				oxidoreductase activity
1.29424	down	Calcyphosin-2 (Calcyphosine-2). [Uniprot/SWISSPROT;Acc:Q9BXY5]	biological process	ciliary or flagellar motility
			cellular component	flagellin-based flagellum
			molecular function	calcium ion binding
1.2984		nucleolar and spindle associated protein 1 isoform 2 [RefSeq_peptide;Acc:NP_060924]	biological process	cytokinesis after mitosis
				establishment of mitotic spindle localization
				mitotic chromosome condensation
				positive regulation of mitosis
			cellular component	nucleolus
				spindle microtubule
			molecular function	microtubule binding
1.29952		Melanoma-associated antigen C2 (MAGE-C2 antigen) (MAGE-E1 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen 10) (CT10). [Uniprot/SWISSPROT;Acc:Q9UBF1]	biological process	regulation of progression through cell cycle
			cellular component	cytoplasm
				nucleus
1.30082		CCR4-NOT transcription complex subunit 2 (CCR4-associated factor 2). [Uniprot/SWISSPROT;Acc:Q9NZN8]	biological process	regulation of global transcription from RNA polymerase II promoter
				regulation of transcription
				regulation of transcription, DNA-dependent
			cellular component	cytoplasm

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.