MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Accession	Gene Ontology	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 651 to 700 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
1.683	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]	RNA binding	molecular function
		rRNA processing	biological process
1.69153	Keratin-associated protein 19-2. [Uniprot/SWISSPROT;Acc:Q3LHN2]	intermediate filament	cellular component
1.693	CDK5 regulatory subunit associated protein 1-like 1 [RefSeq_peptide;Acc:NP_060244]	catalytic activity	molecular function
		iron-sulfur cluster binding
		metabolic process	biological process
1.69658	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase (EC 2.4.99.-) (Beta-galactoside alpha-2,3-sialyltransferase) (Alpha 2,3-sialyltransferase IV) (Alpha 2,3-ST) (Gal-NAc6S) (STZ) (SIAT4-C) (ST3Gal III) (SAT-3) (ST-4). [Uniprot/SWISSPROT;Acc:Q11206]	beta-galactoside alpha-2,3-sialyltransferase activity	molecular function
		Golgi apparatus	cellular component
		integral to Golgi membrane
		integral to membrane
		membrane
		protein amino acid glycosylation	biological process
		sialyltransferase activity	molecular function
		transferase activity, transferring glycosyl groups
1.72628	Coiled-coil domain-containing protein 108. [Uniprot/SWISSPROT;Acc:Q6ZU64]	DNA repair	biological process
		integral to membrane	cellular component
		membrane
		methylated-DNA-[protein]-cysteine S-methyltransferase activity	molecular function
		structural molecule activity
1.72656	protein phosphatase 1, regulatory subunit 15B [RefSeq_peptide;Acc:NP_116222]	ER overload response	biological process
		protein phosphatase type 1 complex	cellular component
		protein serine/threonine phosphatase activity	molecular function
		response to hydrogen peroxide	biological process
		response to oxidative stress
1.73211	Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013]	ATP binding	molecular function
		cell cycle	biological process
		cell proliferation
		chromosome, pericentric region	cellular component
		condensed chromosome
		cytoplasm
		meiosis	biological process
		nucleolus	cellular component
		nucleotide binding	molecular function
		nucleus	cellular component
		protein binding	molecular function
		regulation of progression through cell cycle	biological process
1.74736	Proline-serine-threonine phosphatase-interacting protein 2. [Uniprot/SWISSPROT;Acc:Q9H939]	cytoplasm	cellular component
		membrane
1.75846	Cystinosin. [Uniprot/SWISSPROT;Acc:O60931]	amino acid metabolic process	biological process
		integral to membrane	cellular component
		L-cystine transport	biological process
		L-cystine transporter activity	molecular function
		lysosomal membrane	cellular component
		lysosome
		membrane
		transport	biological process
1.76583	leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745]	aminopeptidase activity	molecular function
		antigen processing and presentation of endogenous peptide antigen via MHC class I	biological process
		blood pressure regulation
		endoplasmic reticulum lumen	cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.