MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 601 to 650 of 2667 in total

Regulation  : down

Ratio	description	Class	Gene Ontology
1.59763	Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]	biological process	ubiquitin cycle
		cellular component	cytoplasm
		molecular function	ATP binding
			ligase activity
			nucleotide binding
			small conjugating protein ligase activity
			ubiquitin-protein ligase activity
1.60746	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Uniprot/SWISSPROT;Acc:Q8TD26]	biological process	chromatin assembly or disassembly
			chromatin remodeling
			nervous system development
			nucleosome assembly
			regulation of transcription, DNA-dependent
			response to antibiotic
			tetracycline transport
			transcription
		cellular component	chromatin
			integral to membrane
			nucleosome
			nucleus
		molecular function	ATP binding
			ATP-dependent helicase activity
			chromatin binding
			DNA binding
			helicase activity
			hydrolase activity
			nucleic acid binding
			nucleotide binding
			tetracycline:hydrogen antiporter activity
1.61347	Calmodulin-like protein 5 (Calmodulin-like skin protein). [Uniprot/SWISSPROT;Acc:Q9NZT1]	biological process	ciliary or flagellar motility
			epidermis development
			signal transduction
		cellular component	flagellin-based flagellum
		molecular function	calcium ion binding
			protein binding
1.65835	Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]	biological process	selenocysteine incorporation
			translational elongation
		cellular component	cytoplasm
			nucleus
		molecular function	GTP binding
			GTPase activity
			nucleotide binding
			translation elongation factor activity
			tRNA binding
1.683	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]	biological process	rRNA processing
		cellular component	cytoplasm
			exosome (RNase complex)
			nucleus
		molecular function	exonuclease activity
			GDP-dissociation stimulator activity
			hydrolase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.