MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 601 to 650 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.25808	up	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]	molecular function	nucleotide binding
1.2734		Neurexin-2-alpha precursor (Neurexin II-alpha). [Uniprot/SWISSPROT;Acc:Q9P2S2]	biological process	cell adhesion
				neurotransmitter secretion
				synaptic transmission
				synaptogenesis
			cellular component	integral to membrane
				membrane
			molecular function	calcium channel regulator activity
				calcium ion binding
				protein binding
1.27461	down	Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]	biological process	anatomical structure morphogenesis
				G-protein coupled receptor protein signaling pathway
				multicellular organismal development
				regulation of transcription, DNA-dependent
				thyroid gland development
			cellular component	integral to membrane
				nucleus
			molecular function	DNA binding
				galanin receptor activity
				sequence-specific DNA binding
				transcription factor activity
1.27516	up	Uncharacterized protein C16orf48. [Uniprot/SWISSPROT;Acc:Q9H0I2]	cellular component	microtubule cytoskeleton
1.27696	down	Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). [Uniprot/SWISSPROT;Acc:Q5MJ70]	biological process	cell cycle
				G1/S transition of mitotic cell cycle
				multicellular organismal development
				positive regulation of cell proliferation
				positive regulation of cyclin-dependent protein kinase activity
				protein amino acid dephosphorylation
				regulation of progression through cell cycle
				response to DNA damage stimulus
			cellular component	nucleus
			molecular function	protein binding
				protein kinase binding
				protein phosphatase type 1 activity
1.27802		Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2). [Uniprot/SWISSPROT;Acc:O15479]	biological process	homoiothermy
				response to freezing
			molecular function	ice binding
				protein binding
1.28319	up	Autophagy-related protein 10 (APG10-like). [Uniprot/SWISSPROT;Acc:Q9H0Y0]	biological process	autophagy
				positive regulation of protein modification
				protein amino acid lipidation
				protein transport
				ubiquitin cycle
			cellular component	cytoplasm
				intracellular
			molecular function	protein binding
1.28356	down	T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207]	biological process	cardiac muscle development
				cell aging
				heart morphogenesis
				homoiothermy

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.