MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Gene Ontology	Regulation	description	Accession	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 601 to 650 of 2667 in total

Ratio	Gene Ontology	Regulation	description	Class
1.25808	transcription	up	Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]	biological process
1.2734	calcium channel regulator activity		Neurexin-2-alpha precursor (Neurexin II-alpha). [Uniprot/SWISSPROT;Acc:Q9P2S2]	molecular function
	calcium ion binding
	cell adhesion			biological process
	integral to membrane			cellular component
	membrane
	neurotransmitter secretion			biological process
	protein binding			molecular function
	synaptic transmission			biological process
	synaptogenesis
1.27461	anatomical structure morphogenesis	down	Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]
	DNA binding			molecular function
	G-protein coupled receptor protein signaling pathway			biological process
	galanin receptor activity			molecular function
	integral to membrane			cellular component
	multicellular organismal development			biological process
	nucleus			cellular component
	regulation of transcription, DNA-dependent			biological process
	sequence-specific DNA binding			molecular function
	thyroid gland development			biological process
	transcription factor activity			molecular function
1.27516	microtubule cytoskeleton	up	Uncharacterized protein C16orf48. [Uniprot/SWISSPROT;Acc:Q9H0I2]	cellular component
1.27696	cell cycle	down	Speedy protein A (Speedy-1) (Spy1) (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A). [Uniprot/SWISSPROT;Acc:Q5MJ70]	biological process
	G1/S transition of mitotic cell cycle
	multicellular organismal development
	nucleus			cellular component
	positive regulation of cell proliferation			biological process
	positive regulation of cyclin-dependent protein kinase activity
	protein amino acid dephosphorylation
	protein binding			molecular function
	protein kinase binding
	protein phosphatase type 1 activity
	regulation of progression through cell cycle			biological process
	response to DNA damage stimulus
1.27802	homoiothermy		Melanoma-associated antigen B2 (MAGE-B2 antigen) (DSS-AHC critical interval MAGE superfamily 6) (DAM6) (MAGE XP-2). [Uniprot/SWISSPROT;Acc:O15479]
	ice binding			molecular function
	protein binding
	response to freezing			biological process
1.28319	autophagy	up	Autophagy-related protein 10 (APG10-like). [Uniprot/SWISSPROT;Acc:Q9H0Y0]
	cytoplasm			cellular component
	intracellular
	positive regulation of protein modification			biological process
	protein amino acid lipidation
	protein binding			molecular function
	protein transport			biological process
	ubiquitin cycle
1.28356	cardiac muscle development	down	T-box transcription factor TBX2 (T-box protein 2). [Uniprot/SWISSPROT;Acc:Q13207]
	cell aging
	heart morphogenesis
	homoiothermy

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.