MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Accession	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 601 to 650 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
1.59763	Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8]	cytoplasm	cellular component
		ligase activity	molecular function
		nucleotide binding
		protein modification process	biological process
		small conjugating protein ligase activity	molecular function
		ubiquitin cycle	biological process
		ubiquitin-protein ligase activity	molecular function
1.60746	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Uniprot/SWISSPROT;Acc:Q8TD26]	ATP binding
		ATP-dependent helicase activity
		chromatin	cellular component
		chromatin assembly or disassembly	biological process
		chromatin binding	molecular function
		chromatin remodeling	biological process
		DNA binding	molecular function
		helicase activity
		hydrolase activity
		integral to membrane	cellular component
		nervous system development	biological process
		nucleic acid binding	molecular function
		nucleosome	cellular component
		nucleosome assembly	biological process
		nucleotide binding	molecular function
		nucleus	cellular component
		regulation of transcription, DNA-dependent	biological process
		response to antibiotic
		tetracycline transport
		tetracycline:hydrogen antiporter activity	molecular function
		transcription	biological process
1.61347	Calmodulin-like protein 5 (Calmodulin-like skin protein). [Uniprot/SWISSPROT;Acc:Q9NZT1]	calcium ion binding	molecular function
		ciliary or flagellar motility	biological process
		epidermis development
		flagellin-based flagellum	cellular component
		protein binding	molecular function
		signal transduction	biological process
1.65835	Selenocysteine-specific elongation factor (Elongation factor sec) (Eukaryotic elongation factor, selenocysteine-tRNA-specific). [Uniprot/SWISSPROT;Acc:P57772]	cytoplasm	cellular component
		GTP binding	molecular function
		GTPase activity
		nucleotide binding
		nucleus	cellular component
		selenocysteine incorporation	biological process
		translation elongation factor activity	molecular function
		translational elongation	biological process
		tRNA binding	molecular function
1.683	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog). [Uniprot/SWISSPROT;Acc:Q9Y2L1]	cytoplasm	cellular component
		exonuclease activity	molecular function
		exosome (RNase complex)	cellular component
		GDP-dissociation stimulator activity	molecular function
		hydrolase activity
		nucleus	cellular component
		ribonuclease activity	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.