MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Accession	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 551 to 600 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.25147	up	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Uniprot/SWISSPROT;Acc:P42081]	positive regulation of interleukin-4 biosynthetic process	biological process
			positive regulation of lymphotoxin A biosynthetic process
			positive regulation of T-helper 2 cell differentiation
			positive regulation of transcription
			protein binding	molecular function
			T cell activation	biological process
			T cell proliferation
			transcriptional activator activity	molecular function
1.25205	down	Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013]	7S RNA binding
			GTP binding
			membrane	cellular component
			nuclear mRNA splicing, via spliceosome	biological process
			nucleus	cellular component
			RNA binding	molecular function
			RNA splicing	biological process
			spliceosome	cellular component
			SRP-dependent cotranslational protein targeting to membrane	biological process
1.25729	up	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-). [Uniprot/SWISSPROT;Acc:Q96LJ7]	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity	molecular function
			endoplasmic reticulum	cellular component
			enterobactin biosynthetic process	biological process
			metabolic process
			mitochondrial inner membrane	cellular component
			oxidoreductase activity	molecular function
1.25808		Chromodomain-helicase-DNA-binding protein 7 (EC 3.6.1.-) (ATP- dependent helicase CHD7) (CHD-7). [Uniprot/SWISSPROT;Acc:Q9P2D1]	adult heart development	biological process
			adult walking behavior
			ATP binding	molecular function
			blood vessel development	biological process
			camera-type eye development
			chromatin	cellular component
			chromatin assembly or disassembly	biological process
			chromatin binding	molecular function
			chromatin modification	biological process
			circulation
			DNA binding	molecular function
			embryonic hindlimb morphogenesis	biological process
			female genitalia development
			heart morphogenesis
			helicase activity	molecular function
			hydrolase activity
			in utero embryonic development	biological process
			inner ear morphogenesis
			locomotory behavior
			nose development
			nucleic acid binding	molecular function
			nucleotide binding
			nucleus	cellular component
			palate development	biological process
			positive regulation of body size
			regulation of transcription, DNA-dependent
			sensory perception of sound

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.