MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 518 to 567 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.24361	down	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase). [Uniprot/SWISSPROT;Acc:P33908]	ER-Golgi intermediate compartment	cellular component
			Golgi apparatus
			hydrolase activity, acting on glycosyl bonds	molecular function
			integral to membrane	cellular component
			mannosidase activity	molecular function
			mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
			membrane	cellular component
			membrane fraction
			metabolic process	biological process
			protein amino acid glycosylation
1.24964		Atlastin-2 (ADP-ribosylation factor-like protein 6-interacting protein 2). [Uniprot/SWISSPROT;Acc:Q8NHH9]	GTP binding	molecular function
			GTPase activity
			immune response	biological process
			integral to membrane	cellular component
			membrane
			nucleotide binding	molecular function
			protein binding
1.25113		Zinc finger protein OZF (Only zinc finger protein) (Zinc finger protein 146). [Uniprot/SWISSPROT;Acc:Q15072]	DNA binding
			heparin binding
			intracellular	cellular component
			metal ion binding	molecular function
			nucleic acid binding
			nucleus	cellular component
			regulation of transcription, DNA-dependent	biological process
			zinc ion binding	molecular function
1.25147	up	T-lymphocyte activation antigen CD86 precursor (Activation B7-2 antigen) (CTLA-4 counter-receptor B7.2) (B70) (FUN-1) (BU63). [Uniprot/SWISSPROT;Acc:P42081]	cell-cell signaling	biological process
			coreceptor activity	molecular function
			external side of plasma membrane	cellular component
			immune response	biological process
			integral to membrane	cellular component
			plasma membrane
			positive regulation of cell proliferation	biological process
			positive regulation of interleukin-2 biosynthetic process
			positive regulation of interleukin-4 biosynthetic process
			positive regulation of lymphotoxin A biosynthetic process
			positive regulation of T-helper 2 cell differentiation
			positive regulation of transcription
			protein binding	molecular function
			T cell activation	biological process
			T cell proliferation
			transcriptional activator activity	molecular function
1.25205	down	Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013]	7S RNA binding
			GTP binding
			membrane	cellular component
			nuclear mRNA splicing, via spliceosome	biological process
			nucleus	cellular component
			RNA binding	molecular function
			RNA splicing	biological process
			spliceosome	cellular component
			SRP-dependent cotranslational protein targeting to membrane	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.