MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Minimum Ratio	Gene Ontology	Accession	description	Class	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 518 to 567 of 2667 in total

Regulation  : down

Ratio	Gene Ontology	description	Class
1.49271	ubiquitin cycle	Cullin-4B (CUL-4B). [Uniprot/SWISSPROT;Acc:Q13620]	biological process
1.49558	BMP signaling pathway	Bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A). [Uniprot/SWISSPROT;Acc:P12643]
	bone mineralization
	cardiac cell differentiation
	cartilage development
	cell fate commitment
	cell growth
	cell-cell signaling
	cytokine activity		molecular function
	embryonic development		biological process
	epithelial to mesenchymal transition
	extracellular region		cellular component
	extracellular space
	growth		biological process
	growth factor activity		molecular function
	inflammatory response		biological process
	negative regulation of cell proliferation
	negative regulation of progression through cell cycle
	odontogenesis (sensu Vertebrata)
	organ morphogenesis
	osteoblast differentiation
	positive regulation of astrocyte differentiation
	positive regulation of ossification
	positive regulation of osteoblast differentiation
	protein binding		molecular function
	regulation of transcription		biological process
	transforming growth factor beta receptor binding		molecular function
	ureteric bud branching		biological process
1.49923	blood vessel development	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP). [Uniprot/SWISSPROT;Acc:Q13905]
	cell-cell adhesion
	guanyl-nucleotide exchange factor activity		molecular function
	intracellular		cellular component
	platelet-derived growth factor receptor signaling pathway		biological process
	protein binding		molecular function
	regulation of small GTPase mediated signal transduction		biological process
	signal transduction
	small GTPase mediated signal transduction
	transmembrane receptor protein tyrosine kinase signaling pathway
1.50284	cytoplasmic vesicle	AP-3 complex subunit sigma-2 (Adapter-related protein complex 3 sigma- 2 subunit) (Sigma-adaptin 3b) (AP-3 complex sigma-3B subunit) (Sigma- 3B-adaptin). [Uniprot/SWISSPROT;Acc:P59780]	cellular component
	Golgi apparatus
	intracellular protein transport		biological process
	membrane		cellular component
	membrane coat
	protein binding		molecular function
	protein complex assembly		biological process
	protein transporter activity		molecular function
	transport		biological process
	vesicle-mediated transport
1.50715	protein binding	F-box/WD repeat protein 5 (F-box and WD-40 domain protein 5). [Uniprot/SWISSPROT;Acc:Q969U6]	molecular function
	ubiquitin cycle		biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.