Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Gene Ontology Accession Regulation Ratio description Minimum Ratio Gene Class Maximum Ratio
Results: HTML CSV LaTeX Showing element 501 to 550 of 1501 in total
Regulation  : up
Gene Ontology
Ratio
description
Class
integral to membrane 1.60668 Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC [Uniprot/SWISSPROT;Acc:Q9HBA0] cellular component
1.61987 Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]
1.63713 Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). [Uniprot/SWISSPROT;Acc:Q9UH62]
1.6384 Olfactory receptor 6S1. [Uniprot/SWISSPROT;Acc:Q8NH40]
1.75026 Claudin-11 (Oligodendrocyte-specific protein). [Uniprot/SWISSPROT;Acc:O75508]
1.83601 coiled-coil domain containing 90A [RefSeq_peptide;Acc:NP_001026883]
1.86433 CKLF-like MARVEL transmembrane domain-containing protein 4 (Chemokine- like factor superfamily member 4). [Uniprot/SWISSPROT;Acc:Q8IZR5]
1.93863 Olfactory receptor 2B2 (Olfactory receptor 6-1) (OR6-1) (Hs6M1-10). [Uniprot/SWISSPROT;Acc:Q9GZK3]
1.96673 Signal peptidase complex catalytic subunit SEC11C (EC 3.4.-.-) (SEC11 homolog C) (SEC11-like protein 3) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SPC21). [Uniprot/SWISSPROT;Acc:Q9BY50]
1.98149 CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]
2.48474 BET1 homolog (Golgi vesicular membrane-trafficking protein p18) (hBET1). [Uniprot/SWISSPROT;Acc:O15155]
2.54508 Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4]
2.57202 Protein GPR107 precursor (Lung seven transmembrane receptor 1). [Uniprot/SWISSPROT;Acc:Q5VW38]
2.86538 Olfactory receptor 1J2 (Olfactory receptor OR9-19) (OST044) (HSA5) (HTPCRX15). [Uniprot/SWISSPROT;Acc:Q8NGS2]
3.14866 Transmembrane protein 181. [Uniprot/SWISSPROT;Acc:Q9P2C4]
3.31364 Diacylglycerol O-acyltransferase 2 (EC 2.3.1.20) (Diglyceride acyltransferase 2). [Uniprot/SWISSPROT;Acc:Q96PD7]
3.41415 Voltage-dependent calcium channel gamma-7 subunit (Neuronal voltage- gated calcium channel gamma-7 subunit). [Uniprot/SWISSPROT;Acc:P62955]
3.76904 Progestin and adipoQ receptor family member 4 (Progestin and adipoQ receptor family member IV). [Uniprot/SWISSPROT;Acc:Q8N4S7]
3.89584 Kremen protein 1 precursor (Kringle-containing protein marking the eye and the nose) (Kringle domain-containing transmembrane protein 1) (Dickkopf receptor). [Uniprot/SWISSPROT;Acc:Q96MU8]
4.04651 Sad1/unc-84-like protein 2 (Rab5-interacting protein) (Rab5IP). [Uniprot/SWISSPROT;Acc:Q9UH99]
4.05743 Clarin-1 (Usher syndrome type-3 protein). [Uniprot/SWISSPROT;Acc:P58418]
4.55371 Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]
4.67988 Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3). [Uniprot/SWISSPROT;Acc:P22001]
5.19755 Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]
integral to plasma membrane 1.15279 Podocalyxin-like protein 2 precursor (Endoglycan). [Uniprot/SWISSPROT;Acc:Q9NZ53]
1.47697 Nck-associated protein 1-like (Membrane-associated protein HEM-1) (Hematopoietic protein 1). [Uniprot/SWISSPROT;Acc:P55160]
1.61987 Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor). [Uniprot/SWISSPROT;Acc:P25116]
1.98149 CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (TNF-related activation protein) (TRAP) (T cell antigen Gp39) (CD154 antigen) [Contains: CD40 ligand, membrane form; CD40 ligand, soluble form]. [Uniprot/SWISSPROT;Acc:P29965]
2.8521 transient receptor potential cation channel, subfamily M, member 1 [RefSeq_peptide;Acc:NP_002411]
3.48558 Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2) (Tyrosine-protein kinase TYRO6). [Uniprot/SWISSPROT;Acc:P54753]
4.03725 Receptor-type tyrosine-protein phosphatase epsilon precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon). [Uniprot/SWISSPROT;Acc:P23469]
4.55371 Parathyroid hormone/parathyroid hormone-related peptide receptor precursor (PTH/PTHr receptor) (PTH/PTHrP type I receptor). [Uniprot/SWISSPROT;Acc:Q03431]
integrin binding 1.16499 ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1] molecular function
intercellular junction maintenance 2.54508 Neuroligin-2 precursor. [Uniprot/SWISSPROT;Acc:Q8NFZ4] biological process
interleukin-1 receptor complex 3.54414 Toll-interacting protein. [Uniprot/SWISSPROT;Acc:Q9H0E2] cellular component
interleukin-18 receptor complex
intracellular 1.13007 Zinc finger protein 219. [Uniprot/SWISSPROT;Acc:Q9P2Y4]
1.19207 Nuclear RNA export factor 2 (TAP-like protein 2) (TAPL-2). [Uniprot/SWISSPROT;Acc:Q9GZY0]
1.28319 Autophagy-related protein 10 (APG10-like). [Uniprot/SWISSPROT;Acc:Q9H0Y0]
1.34491 Bardet-Biedl syndrome 5 protein. [Uniprot/SWISSPROT;Acc:Q8N3I7]
1.35022 N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)]. [Uniprot/SWISSPROT;Acc:O15527]
1.36997 Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73 kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Sarcoma antigen NY-SAR-88). [Uniprot/SWISSPROT;Acc:Q8N264]
1.40602 GTP-binding protein SAR1a (COPII-associated small GTPase). [Uniprot/SWISSPROT;Acc:Q9NR31]
1.42264 RNA-binding protein 4 (RNA-binding motif protein 4) (RNA-binding motif protein 4a) (Lark homolog) (hLark). [Uniprot/SWISSPROT;Acc:Q9BWF3]
1.57088 Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein). [Uniprot/SWISSPROT;Acc:O15409]
1.59188 Zinc finger protein 384 (Nuclear matrix transcription factor 4) (Nuclear matrix protein 4) (CAG repeat protein 1) (CAS-interacting zinc finger protein) (Trinucleotide repeat-containing gene 1 protein). [Uniprot/SWISSPROT;Acc:Q8TF68]
1.65422 Uncharacterized protein C9orf117. [Uniprot/SPTREMBL;Acc:Q5JU67]
1.66123 KRAB-A domain containing 1 (KRBA1), mRNA [RefSeq_dna;Acc:NM_032534]
1.79094 Protein FAM65A. [Uniprot/SWISSPROT;Acc:Q6ZS17]
1.7961 RAS-like, family 11, member A [RefSeq_peptide;Acc:NP_996563]

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/