MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Minimum Ratio	Accession	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 501 to 550 of 1501 in total

Regulation  : up

Ratio	description	Gene Ontology	Class
1.35125	Geminin. [Uniprot/SWISSPROT;Acc:O75496]	negative regulation of DNA replication	biological process
		negative regulation of progression through cell cycle
		nucleus	cellular component
		organ morphogenesis	biological process
		protein binding	molecular function
		regulation of progression through cell cycle	biological process
1.36997	Rho GTPase-activating protein 24 (Rho-type GTPase-activating protein 24) (Filamin-A-associated RhoGAP) (FilGAP) (p73RhoGAP) (RhoGAP of 73 kDa) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Sarcoma antigen NY-SAR-88). [Uniprot/SWISSPROT;Acc:Q8N264]	angiogenesis
		cell differentiation
		cell junction	cellular component
		cytoplasm
		cytoskeleton
		GTPase activator activity	molecular function
		intracellular	cellular component
		membrane
		multicellular organismal development	biological process
		protein binding	molecular function
		signal transduction	biological process
1.37411	Lariat debranching enzyme (EC 3.1.-.-). [Uniprot/SWISSPROT;Acc:Q9UK59]	hydrolase activity	molecular function
		hydrolase activity, acting on ester bonds
		metal ion binding
		mRNA processing	biological process
		nuclear mRNA splicing, via spliceosome
		nucleus	cellular component
		RNA lariat debranching enzyme activity	molecular function
		RNA splicing, via transesterification reactions	biological process
1.37553	NULL	peptidyl-prolyl cis-trans isomerase activity	molecular function
		protein folding	biological process
1.37801	Glycerophosphodiester phosphodiesterase domain-containing protein 2 (EC 3.1.-.-) (Glycerophosphodiester phosphodiesterase 3) (Osteoblast differentiation promoting factor). [Uniprot/SWISSPROT;Acc:Q9HCC8]	cytoplasm	cellular component
		cytoskeleton
		glycerol metabolic process	biological process
		glycerophosphodiester phosphodiesterase activity	molecular function
		hydrolase activity
		integral to membrane	cellular component
		membrane
		metabolic process	biological process
1.39878	ATPase family AAA domain-containing protein 2B. [Uniprot/SWISSPROT;Acc:Q9ULI0]	ATP binding	molecular function
		nucleoside-triphosphatase activity
		nucleotide binding
1.40093	NULL	protein binding
1.40602	GTP-binding protein SAR1a (COPII-associated small GTPase). [Uniprot/SWISSPROT;Acc:Q9NR31]	cytoplasm	cellular component
		endoplasmic reticulum
		ER to Golgi vesicle-mediated transport	biological process
		Golgi apparatus	cellular component
		GTP binding	molecular function
		GTPase activity
		intracellular	cellular component
		intracellular protein transport	biological process
		nucleotide binding	molecular function
		small GTPase mediated signal transduction	biological process
1.40749	collagen, type XXVII, alpha 1 [RefSeq_peptide;Acc:NP_116277]	cell adhesion

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.