MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Regulation	Ratio	description	Accession	Gene Ontology	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 51 to 100 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
1.18096	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]	anagen	biological process
		blood pressure regulation
		caveolar membrane	cellular component
		cell motility	biological process
		cyclooxygenase pathway
		cytoplasm	cellular component
		electron transport	biological process
		endoplasmic reticulum	cellular component
		fatty acid biosynthetic process	biological process
		heme binding	molecular function
		iron ion binding
		membrane	cellular component
		metal ion binding	molecular function
		microsome	cellular component
		negative regulation of cell proliferation	biological process
		nucleus	cellular component
		oxidoreductase activity	molecular function
		oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
		peroxidase activity
		prostaglandin-endoperoxide synthase activity
		protein binding
		protein complex	cellular component
		regulation of inflammatory response	biological process
		regulation of progression through cell cycle
		response to oxidative stress
1.18141	Ketosamine-3-kinase (EC 2.7.1.-) (Fructosamine-3-kinase-related protein). [Uniprot/SWISSPROT;Acc:Q9HA64]	kinase activity	molecular function
		transferase activity
1.18821	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Uniprot/SWISSPROT;Acc:P32927]	cytokine and chemokine mediated signaling pathway	biological process
		granulocyte macrophage colony-stimulating factor receptor complex	cellular component
		hematopoietin/interferon-class (D200-domain) cytokine receptor activity	molecular function
		integral to membrane	cellular component
		interleukin receptor activity	molecular function
		interleukin-3 receptor activity
		interleukin-5 receptor activity
		membrane	cellular component
		receptor activity	molecular function
		respiratory gaseous exchange	biological process
		signal transduction
1.19134	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]	calcium ion binding	molecular function
		cell-cell signaling	biological process
		determination of left/right symmetry
		endoplasmic reticulum	cellular component
		intracellular
		membrane
		nucleic acid binding	molecular function
		peptidase activity
		proteolysis	biological process
		subtilase activity	molecular function
		zinc ion binding
		zygotic determination of anterior/posterior axis, embryo	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.