MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	description	Ratio	Class	Gene	Accession	Gene Ontology	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 468 to 517 of 2667 in total

Regulation  : down

description	Ratio	Class	Gene Ontology
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta 2 (Transducin beta chain 2) (G protein beta 2 subunit). [Uniprot/SWISSPROT;Acc:P62879]	3.54799	biological process	G-protein coupled receptor protein signaling pathway
			signal transduction
		molecular function	calcium channel regulator activity
			GTPase activity
			protein binding
			signal transducer activity
Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]	1.1611	biological process	electron transport
			signal transduction
		cellular component	extracellular region
		molecular function	electron carrier activity
			enzyme activator activity
			guanylate cyclase activator activity
			hormone activity
Hematological and neurological expressed 1 protein (Androgen-regulated protein 2). [Uniprot/SWISSPROT;Acc:Q9UK76]	3.62109	cellular component	nucleus
Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249]	1.27461	biological process	anatomical structure morphogenesis
			G-protein coupled receptor protein signaling pathway
			multicellular organismal development
			regulation of transcription, DNA-dependent
			thyroid gland development
		cellular component	integral to membrane
			nucleus
		molecular function	DNA binding
			galanin receptor activity
			sequence-specific DNA binding
			transcription factor activity
Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGFB-induced factor 2) (TGF(beta)-induced transcription factor 2). [Uniprot/SWISSPROT;Acc:Q9GZN2]	3.48313	biological process	regulation of transcription, DNA-dependent
		cellular component	nucleus
		molecular function	sequence-specific DNA binding
			transcription factor activity
Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	1.23845	biological process	cell proliferation
			cholesterol metabolic process
			lipid metabolic process
			metabolic process
			response to sterol depletion
			steroid metabolic process
		cellular component	endoplasmic reticulum
			integral to membrane
			membrane
		molecular function	protein binding
Inter-alpha-trypsin inhibitor heavy chain H2 precursor (ITI heavy chain H2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP). [Uniprot/SWISSPROT;Acc:P19823]	2.08208	biological process	hyaluronan metabolic process
		cellular component	extracellular region
		molecular function	serine-type endopeptidase inhibitor activity
Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]	1.43088	biological process	carotenoid biosynthetic process
			cholesterol biosynthetic process
			isoprenoid biosynthetic process
		cellular component	peroxisome
		molecular function	hydrolase activity
			isomerase activity
			isopentenyl-diphosphate delta-isomerase activity
			magnesium ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.