MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 468 to 517 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.22576	up	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]	molecular function	transcription factor activity
				zinc ion binding
1.22694		Protein FAM73B. [Uniprot/SPTREMBL;Acc:Q7L4E1]	biological process	type I hypersensitivity
1.23668	down	Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160]		biological_process
			cellular component	myosin complex
				unconventional myosin complex
			molecular function	actin binding
				ATP binding
				calmodulin binding
				motor activity
				nucleoside-triphosphatase activity
				nucleotide binding
1.23783		Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Uniprot/SWISSPROT;Acc:Q8WZ64]	biological process	regulation of GTPase activity
				signal transduction
			cellular component	cytoplasm
				intracellular
			molecular function	GTPase activator activity
				metal ion binding
				phosphatidylinositol-3,4,5-triphosphate binding
				zinc ion binding
1.23845		Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	biological process	cell proliferation
				cholesterol metabolic process
				lipid metabolic process
				metabolic process
				response to sterol depletion
				steroid metabolic process
			cellular component	endoplasmic reticulum
				integral to membrane
				membrane
			molecular function	protein binding
1.24114		Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]	biological process	signal transduction
				striated muscle contraction
			cellular component	intracellular
				myosin complex
				striated muscle thick filament
			molecular function	actin binding
				ATP binding
				calmodulin binding
				motor activity
				nucleotide binding
1.24359		Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2). [Uniprot/SWISSPROT;Acc:Q86UW7]	biological process	exocytosis
				protein transport
			cellular component	cell junction
				cytoplasmic vesicle
				membrane
				synapse
			molecular function	calcium ion binding
				lipid binding
1.24361		Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC 3.2.1.113) (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase). [Uniprot/SWISSPROT;Acc:P33908]	biological process	metabolic process
				protein amino acid glycosylation

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.