MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	Accession	description	Class	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 451 to 500 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
1.22502	up	transporter activity	ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Uniprot/SWISSPROT;Acc:Q99758]	molecular function
1.22528		dephosphorylation	protein tyrosine phosphatase domain containing 1 protein isoform 2 [RefSeq_peptide;Acc:NP_818931]	biological process
		hydrolase activity		molecular function
		phosphoric monoester hydrolase activity
		protein amino acid dephosphorylation		biological process
		protein tyrosine phosphatase activity		molecular function
		protein tyrosine/serine/threonine phosphatase activity
1.22576		DNA binding	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]
		metal ion binding
		methyl-CpG binding
		negative regulation of transcription		biological process
		nucleus		cellular component
		protein binding		molecular function
		regulation of transcription, DNA-dependent		biological process
		transcription
		transcription corepressor activity		molecular function
		transcription factor activity
		transcription from RNA polymerase II promoter		biological process
		zinc ion binding		molecular function
1.22694		type I hypersensitivity	Protein FAM73B. [Uniprot/SPTREMBL;Acc:Q7L4E1]	biological process
1.23668	down	actin binding	Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160]	molecular function
		ATP binding
		biological_process		biological process
		calmodulin binding		molecular function
		motor activity
		myosin complex		cellular component
		nucleoside-triphosphatase activity		molecular function
		nucleotide binding
		unconventional myosin complex		cellular component
1.23783		cytoplasm	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein). [Uniprot/SWISSPROT;Acc:Q8WZ64]
		GTPase activator activity		molecular function
		intracellular		cellular component
		metal ion binding		molecular function
		phosphatidylinositol-3,4,5-triphosphate binding
		regulation of GTPase activity		biological process
		signal transduction
		zinc ion binding		molecular function
1.23845		cell proliferation	Insulin-induced gene 1 protein (INSIG-1). [Uniprot/SWISSPROT;Acc:O15503]	biological process
		cholesterol metabolic process
		endoplasmic reticulum		cellular component
		integral to membrane
		lipid metabolic process		biological process
		membrane		cellular component
		metabolic process		biological process
		protein binding		molecular function
		response to sterol depletion		biological process
		steroid metabolic process
1.24114		actin binding	Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3]	molecular function
		ATP binding
		calmodulin binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.