MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 419 to 468 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.21871	down	Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Uniprot/SWISSPROT;Acc:Q13323]	biological process	induction of apoptosis
				regulation of apoptosis
			cellular component	integral to membrane
				membrane
				mitochondrial envelope
			molecular function	protein binding
1.22047	up	HORMA domain-containing protein 1 (Newborn ovary HORMA protein) (Cancer/testis antigen CT46). [Uniprot/SWISSPROT;Acc:Q86X24]	biological process	mitosis
			cellular component	nucleus
1.22178		Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]	biological process	protein amino acid phosphorylation
			cellular component	cytoplasm
				cytosol
				nucleus
			molecular function	ATP binding
				heme binding
				nucleotide binding
				protein binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
				transition metal ion binding
1.22502		ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Uniprot/SWISSPROT;Acc:Q99758]	biological process	response to drug
				transport
			cellular component	integral to membrane
				lamellar body
				membrane fraction
				plasma membrane
			molecular function	ATP binding
				ATPase activity
				ATPase activity, coupled to transmembrane movement of substances
				nucleoside-triphosphatase activity
				nucleotide binding
				transporter activity
1.22528		protein tyrosine phosphatase domain containing 1 protein isoform 2 [RefSeq_peptide;Acc:NP_818931]	biological process	dephosphorylation
				protein amino acid dephosphorylation
			molecular function	hydrolase activity
				phosphoric monoester hydrolase activity
				protein tyrosine phosphatase activity
				protein tyrosine/serine/threonine phosphatase activity
1.22576		Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]	biological process	negative regulation of transcription
				regulation of transcription, DNA-dependent
				transcription
				transcription from RNA polymerase II promoter
			cellular component	nucleus
			molecular function	DNA binding
				metal ion binding
				methyl-CpG binding
				protein binding
				transcription corepressor activity
				transcription factor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.