MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Regulation	Ratio	Gene Ontology	description	Accession	Class	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 418 to 467 of 2667 in total

Regulation  : down

Ratio	Gene Ontology	description	Class
1.36755	biological_process	Nucleolar preribosomal-associated protein 1 (Fragment). [Uniprot/SWISSPROT;Acc:O60287]	biological process
	molecular_function		molecular function
	nucleolus		cellular component
	nucleus
1.36911	bombesin receptor activity	Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). [Uniprot/SWISSPROT;Acc:Q96P65]	molecular function
	G-protein coupled receptor protein signaling pathway		biological process
	integral to membrane		cellular component
	membrane
	metabotropic glutamate, GABA-B-like receptor activity		molecular function
	neuropeptide receptor activity
	neuropeptide Y receptor activity
	orexin receptor activity
	purinergic nucleotide receptor activity, G-protein coupled
	receptor activity
	rhodopsin-like receptor activity
	signal transduction		biological process
1.40451	integral to membrane	COX16-like protein C14orf112, mitochondrial precursor. [Uniprot/SWISSPROT;Acc:Q9P0S2]	cellular component
	membrane
	mitochondrion
1.40552	amino acid metabolic process	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76]	biological process
	amino acid transport
	amino acid transporter activity		molecular function
	dicarboxylic acid transport		biological process
	integral to plasma membrane		cellular component
	membrane
	neurotransmitter transport		biological process
	neurotransmitter:sodium symporter activity		molecular function
	sodium:dicarboxylate symporter activity
	symporter activity
1.41851	insulin receptor binding	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]
	MAPKKK cascade		biological process
	nervous system development
	transmembrane receptor protein tyrosine kinase signaling pathway
	transmembrane receptor protein tyrosine kinase signaling protein activity		molecular function
1.42215	integral to plasma membrane	Sodium-dependent serotonin transporter (5HT transporter) (5HTT). [Uniprot/SWISSPROT;Acc:P31645]	cellular component
	membrane
	monoamine transport		biological process
	monoamine transporter activity		molecular function
	neurotransmitter transport		biological process
	neurotransmitter uptake
	neurotransmitter:sodium symporter activity		molecular function
	protein binding
	serotonin transport		biological process
	serotonin transporter activity		molecular function
	serotonin:sodium symporter activity
	symporter activity
1.43088	carotenoid biosynthetic process	Isopentenyl-diphosphate Delta-isomerase 2 (EC 5.3.3.2) (IPP isomerase 2) (Isopentenyl pyrophosphate isomerase 2) (IPPI2). [Uniprot/SWISSPROT;Acc:Q9BXS1]	biological process
	cholesterol biosynthetic process
	hydrolase activity		molecular function
	isomerase activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.