MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	Gene Ontology	description	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 401 to 450 of 2667 in total

Ratio	Regulation	Gene Ontology	description	Class
1.21657	up	syntaxin binding	Septin-5 (Peanut-like protein 1) (Cell division control-related protein 1) (CDCrel-1). [Uniprot/SWISSPROT;Acc:Q99719]	molecular function
1.21698		electron transport	Kelch-like protein 34. [Uniprot/SWISSPROT;Acc:Q8N239]	biological process
		metabolic process
		oxidoreductase activity		molecular function
		protein binding
1.21705		ATP binding	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta). [Uniprot/SWISSPROT;Acc:P78371]
		cellular protein metabolic process		biological process
		chaperonin-containing T-complex		cellular component
		cytoplasm
		cytosol
		nucleotide binding		molecular function
		protein amino acid phosphorylation		biological process
		protein binding		molecular function
		protein folding		biological process
		protein kinase activity		molecular function
		regulation of progression through cell cycle		biological process
		unfolded protein binding		molecular function
1.21871	down	apoptotic program	Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Uniprot/SWISSPROT;Acc:Q13323]	biological process
		induction of apoptosis
		integral to membrane		cellular component
		membrane
		mitochondrial envelope
		protein binding		molecular function
		regulation of apoptosis		biological process
1.22047	up	mitosis	HORMA domain-containing protein 1 (Newborn ovary HORMA protein) (Cancer/testis antigen CT46). [Uniprot/SWISSPROT;Acc:Q86X24]
		nucleus		cellular component
1.22178		ATP binding	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]	molecular function
		cytoplasm		cellular component
		cytosol
		heme binding		molecular function
		nucleotide binding
		nucleus		cellular component
		protein amino acid phosphorylation		biological process
		protein binding		molecular function
		protein kinase activity
		protein serine/threonine kinase activity
		protein-tyrosine kinase activity
		transferase activity
		transition metal ion binding
1.22502		ATP binding	ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Uniprot/SWISSPROT;Acc:Q99758]
		ATPase activity
		ATPase activity, coupled to transmembrane movement of substances
		integral to membrane		cellular component
		lamellar body
		membrane fraction
		nucleoside-triphosphatase activity		molecular function
		nucleotide binding
		plasma membrane		cellular component
		response to drug		biological process
		transport

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.