MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	Gene Ontology	description	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 401 to 450 of 2667 in total

Regulation  : down

Ratio	Gene Ontology	description	Class
1.31489	protein binding	Tripartite motif-containing protein 58 (Protein BIA2). [Uniprot/SWISSPROT;Acc:Q8NG06]	molecular function
	zinc ion binding
1.32602	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	CDNA: FLJ22222 fis, clone HRC01658. [Uniprot/SPTREMBL;Acc:Q9H6J2]
	protein metabolic process		biological process
1.33817	autophagic vacuole	Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) (Early estrogen-regulated protein). [Uniprot/SWISSPROT;Acc:Q9H0R8]	cellular component
	autophagic vacuole formation		biological process
	beta-tubulin binding		molecular function
	cytoplasm		cellular component
	GABA receptor binding		molecular function
	intracellular		cellular component
	microtubule
	protein binding		molecular function
1.351	dopamine receptor activity	TBK1 binding protein 1 [RefSeq_peptide;Acc:NP_055541]
	G-protein coupled receptor protein signaling pathway		biological process
	integral to membrane		cellular component
1.36349	regulation of progression through cell cycle	Cyclin-I. [Uniprot/SWISSPROT;Acc:Q14094]	biological process
	spermatogenesis
1.36755	biological_process	Nucleolar preribosomal-associated protein 1 (Fragment). [Uniprot/SWISSPROT;Acc:O60287]
	molecular_function		molecular function
	nucleolus		cellular component
	nucleus
1.36911	bombesin receptor activity	Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). [Uniprot/SWISSPROT;Acc:Q96P65]	molecular function
	G-protein coupled receptor protein signaling pathway		biological process
	integral to membrane		cellular component
	membrane
	metabotropic glutamate, GABA-B-like receptor activity		molecular function
	neuropeptide receptor activity
	neuropeptide Y receptor activity
	orexin receptor activity
	purinergic nucleotide receptor activity, G-protein coupled
	receptor activity
	rhodopsin-like receptor activity
	signal transduction		biological process
1.40451	integral to membrane	COX16-like protein C14orf112, mitochondrial precursor. [Uniprot/SWISSPROT;Acc:Q9P0S2]	cellular component
	membrane
	mitochondrion
1.40552	amino acid metabolic process	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76]	biological process
	amino acid transport
	amino acid transporter activity		molecular function
	dicarboxylic acid transport		biological process
	integral to plasma membrane		cellular component
	membrane
	neurotransmitter transport		biological process
	neurotransmitter:sodium symporter activity		molecular function
	sodium:dicarboxylate symporter activity
	symporter activity
1.41851	insulin receptor binding	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]
	MAPKKK cascade		biological process
	nervous system development
	transmembrane receptor protein tyrosine kinase signaling pathway

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.