MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Ratio	description	Gene Ontology	Class	Accession	Minimum Ratio	Gene	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 401 to 450 of 2667 in total

Regulation  : down

Ratio	description	Gene Ontology	Class
1.31489	Tripartite motif-containing protein 58 (Protein BIA2). [Uniprot/SWISSPROT;Acc:Q8NG06]	protein binding	molecular function
		zinc ion binding
1.32602	CDNA: FLJ22222 fis, clone HRC01658. [Uniprot/SPTREMBL;Acc:Q9H6J2]	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
		protein metabolic process	biological process
1.33817	Gamma-aminobutyric acid receptor-associated protein-like 1 (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1) (Early estrogen-regulated protein). [Uniprot/SWISSPROT;Acc:Q9H0R8]	autophagic vacuole	cellular component
		autophagic vacuole formation	biological process
		beta-tubulin binding	molecular function
		cytoplasm	cellular component
		GABA receptor binding	molecular function
		intracellular	cellular component
		microtubule
		protein binding	molecular function
1.351	TBK1 binding protein 1 [RefSeq_peptide;Acc:NP_055541]	dopamine receptor activity
		G-protein coupled receptor protein signaling pathway	biological process
		integral to membrane	cellular component
1.36349	Cyclin-I. [Uniprot/SWISSPROT;Acc:Q14094]	regulation of progression through cell cycle	biological process
		spermatogenesis
1.36755	Nucleolar preribosomal-associated protein 1 (Fragment). [Uniprot/SWISSPROT;Acc:O60287]	biological_process
		molecular_function	molecular function
		nucleolus	cellular component
		nucleus
1.36911	Orexigenic neuropeptide QRFP receptor (G-protein coupled receptor 103) (SP9155) (AQ27). [Uniprot/SWISSPROT;Acc:Q96P65]	bombesin receptor activity	molecular function
		G-protein coupled receptor protein signaling pathway	biological process
		integral to membrane	cellular component
		membrane
		metabotropic glutamate, GABA-B-like receptor activity	molecular function
		neuropeptide receptor activity
		neuropeptide Y receptor activity
		orexin receptor activity
		purinergic nucleotide receptor activity, G-protein coupled
		receptor activity
		rhodopsin-like receptor activity
		signal transduction	biological process
1.40451	COX16-like protein C14orf112, mitochondrial precursor. [Uniprot/SWISSPROT;Acc:Q9P0S2]	integral to membrane	cellular component
		membrane
		mitochondrion
1.40552	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76]	amino acid metabolic process	biological process
		amino acid transport
		amino acid transporter activity	molecular function
		dicarboxylic acid transport	biological process
		integral to plasma membrane	cellular component
		membrane
		neurotransmitter transport	biological process
		neurotransmitter:sodium symporter activity	molecular function
		sodium:dicarboxylate symporter activity
		symporter activity
1.41851	Docking protein 5 (Downstream of tyrosine kinase 5) (IRS6) (Protein dok-5). [Uniprot/SWISSPROT;Acc:Q9P104]	insulin receptor binding
		MAPKKK cascade	biological process
		nervous system development
		transmembrane receptor protein tyrosine kinase signaling pathway

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.