MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 319 to 368 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
1.19545	up	Deoxyribonuclease-2-alpha precursor (EC 3.1.22.1) (Deoxyribonuclease II alpha) (DNase II alpha) (Acid DNase) (Lysosomal DNase II) (R31240_2). [Uniprot/SWISSPROT;Acc:O00115]	molecular function	endonuclease activity
				hormone activity
				hydrolase activity
				protein binding
1.20102		Metalloreductase STEAP3 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde) (Dudulin-2). [Uniprot/SWISSPROT;Acc:Q658P3]	biological process	apoptosis
				cell cycle
				electron transport
				ion transport
				iron ion transport
			cellular component	endosome
				integral to membrane
				membrane
				plasma membrane
			molecular function	copper ion binding
				FAD binding
				ferric-chelate reductase activity
				iron ion binding
				metal ion binding
				oxidoreductase activity
1.20481	down	Neurosecretory protein VGF precursor. [Uniprot/SWISSPROT;Acc:O15240]	biological process	biological_process
				generation of precursor metabolites and energy
				ovarian follicle development
				sexual reproduction
			cellular component	cellular_component
				cytoplasmic vesicle
			molecular function	growth factor activity
				neuropeptide hormone activity
1.20619		Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]	biological process	ATP hydrolysis coupled proton transport
				cation transport
				hydrogen ion homeostasis
				metabolic process
				monovalent inorganic cation transport
				potassium ion transport
				proton transport
				sodium ion transport
				sperm motility
				transport
			cellular component	integral to membrane
				membrane
				sodium:potassium-exchanging ATPase complex
			molecular function	ATP binding
				ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
				catalytic activity
				GABA-B receptor activity
				hydrolase activity
				hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
				magnesium ion binding
				monovalent inorganic cation transporter activity
				nucleotide binding
				potassium ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.